A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals

A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals

Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to understand mechanisms underlying the onset of disease and inflammatory characteristics of relapses and remission. Mouse models in which colitis-like symptoms are induced through challenge with toxins...

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Bibliographic Details
Main Authors: Pia Palamides, Henrika Jodeleit, Michael Föhlinger, Florian Beigel, Nadja Herbach, Thomas Mueller, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp
Format: Article
Language:English
Published: The Company of Biologists 2016-09-01
Series:Disease Models & Mechanisms
Subjects:
Ulcerative colitis
NSG mice
Infliximab
Pitrakinra
Online Access:http://dmm.biologists.org/content/9/9/985

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