Glycation Leads to Increased Polysialylation and Promotes the Metastatic Potential of Neuroblastoma Cells

Glycation Leads to Increased Polysialylation and Promotes the Metastatic Potential of Neuroblastoma Cells

Neuroblastoma is the second most frequent extracranial tumor, affecting young children worldwide. One hallmark of tumors such as neuroblastomas, is the expression of polysialic acid, which interferes with adhesion and may promote invasion and metastasis. Since tumor cells use glycolysis for energy p...

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Bibliographic Details
Main Authors: Maximilian Scheer, Kaya Bork, Frieder Simon, Manimozhi Nagasundaram, Rüdiger Horstkorte, Vinayaga Srinivasan Gnanapragassam
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
(poly) sialic acid
NCAM
adhesion
migration
methylglyoxal
Kelly cells
Online Access:https://www.mdpi.com/2073-4409/9/4/868

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