SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression
Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory distress that has emerged from the city of Wuhan, Hubei province, China during December 2019. COVID-19 is currently the major global health pr...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-024-02342-w |
| _version_ | 1797233838880980992 |
|---|---|
| author | Hosni A. M. Hussein Ali A. Thabet Ahmed A. Wardany Ahmed M. El-Adly Mohamed Ali Mohamed E. A. Hassan Mohamed A. B. Abdeldayem Abdul-Rahman M. A. Mohamed Ali Sobhy Mohamed A. El-Mokhtar Magdy M. Afifi Samah M. Fathy Serageldeen Sultan |
| author_facet | Hosni A. M. Hussein Ali A. Thabet Ahmed A. Wardany Ahmed M. El-Adly Mohamed Ali Mohamed E. A. Hassan Mohamed A. B. Abdeldayem Abdul-Rahman M. A. Mohamed Ali Sobhy Mohamed A. El-Mokhtar Magdy M. Afifi Samah M. Fathy Serageldeen Sultan |
| author_sort | Hosni A. M. Hussein |
| collection | DOAJ |
| description | Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory distress that has emerged from the city of Wuhan, Hubei province, China during December 2019. COVID-19 is currently the major global health problem and the disease has now spread to most countries in the world. COVID-19 has profoundly impacted human health and activities worldwide. Genetic mutation is one of the essential characteristics of viruses. They do so to adapt to their host or to move to another one. Viral genetic mutations have a high potentiality to impact human health as these mutations grant viruses unique unpredicted characteristics. The difficulty in predicting viral genetic mutations is a significant obstacle in the field. Evidence indicates that SARS-CoV-2 has a variety of genetic mutations and genomic diversity with obvious clinical consequences and implications. In this review, we comprehensively summarized and discussed the currently available knowledge regarding SARS-CoV-2 outbreaks with a fundamental focus on the role of the viral proteins and their mutations in viral infection and COVID-19 progression. We also summarized the clinical implications of SARS-CoV-2 variants and how they affect the disease severity and hinder vaccine development. Finally, we provided a massive phylogenetic analysis of the spike gene of 214 SARS-CoV-2 isolates from different geographical regions all over the world and their associated clinical implications. |
| first_indexed | 2024-04-24T16:22:32Z |
| format | Article |
| id | doaj.art-8ffb7a4d67464c33949bf98587420915 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-24T16:22:32Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-8ffb7a4d67464c33949bf985874209152024-03-31T11:10:31ZengBMCVirology Journal1743-422X2024-03-0121111510.1186/s12985-024-02342-wSARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progressionHosni A. M. Hussein0Ali A. Thabet1Ahmed A. Wardany2Ahmed M. El-Adly3Mohamed Ali4Mohamed E. A. Hassan5Mohamed A. B. Abdeldayem6Abdul-Rahman M. A. Mohamed7Ali Sobhy8Mohamed A. El-Mokhtar9Magdy M. Afifi10Samah M. Fathy11Serageldeen Sultan12Department of Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Zoology, Faculty of Science, Al-Azhar UniversityDepartment of Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Clinical Pathology, Faculty of Medicine, Al-Azhar UniversityDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut UniversityDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar UniversityDepartment of Zoology, Faculty of Science, Fayoum UniversityDepartment of Microbiology, Virology Division, Faculty of Veterinary medicine, South Valley UniversityAbstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory distress that has emerged from the city of Wuhan, Hubei province, China during December 2019. COVID-19 is currently the major global health problem and the disease has now spread to most countries in the world. COVID-19 has profoundly impacted human health and activities worldwide. Genetic mutation is one of the essential characteristics of viruses. They do so to adapt to their host or to move to another one. Viral genetic mutations have a high potentiality to impact human health as these mutations grant viruses unique unpredicted characteristics. The difficulty in predicting viral genetic mutations is a significant obstacle in the field. Evidence indicates that SARS-CoV-2 has a variety of genetic mutations and genomic diversity with obvious clinical consequences and implications. In this review, we comprehensively summarized and discussed the currently available knowledge regarding SARS-CoV-2 outbreaks with a fundamental focus on the role of the viral proteins and their mutations in viral infection and COVID-19 progression. We also summarized the clinical implications of SARS-CoV-2 variants and how they affect the disease severity and hinder vaccine development. Finally, we provided a massive phylogenetic analysis of the spike gene of 214 SARS-CoV-2 isolates from different geographical regions all over the world and their associated clinical implications.https://doi.org/10.1186/s12985-024-02342-wCOVID-19Clinical implicationsMutationSARS-CoV-2Spike ProteinVariants |
| spellingShingle | Hosni A. M. Hussein Ali A. Thabet Ahmed A. Wardany Ahmed M. El-Adly Mohamed Ali Mohamed E. A. Hassan Mohamed A. B. Abdeldayem Abdul-Rahman M. A. Mohamed Ali Sobhy Mohamed A. El-Mokhtar Magdy M. Afifi Samah M. Fathy Serageldeen Sultan SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression Virology Journal COVID-19 Clinical implications Mutation SARS-CoV-2 Spike Protein Variants |
| title | SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression |
| title_full | SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression |
| title_fullStr | SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression |
| title_full_unstemmed | SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression |
| title_short | SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression |
| title_sort | sars cov 2 outbreak role of viral proteins and genomic diversity in virus infection and covid 19 progression |
| topic | COVID-19 Clinical implications Mutation SARS-CoV-2 Spike Protein Variants |
| url | https://doi.org/10.1186/s12985-024-02342-w |
| work_keys_str_mv | AT hosniamhussein sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT aliathabet sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT ahmedawardany sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT ahmedmeladly sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT mohamedali sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT mohamedeahassan sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT mohamedababdeldayem sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT abdulrahmanmamohamed sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT alisobhy sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT mohamedaelmokhtar sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT magdymafifi sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT samahmfathy sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression AT serageldeensultan sarscov2outbreakroleofviralproteinsandgenomicdiversityinvirusinfectionandcovid19progression |