Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy
Abstract Background Infiltration of the surgical site with local anesthetics combined with nonsteroidal anti-inflammatory drugs may play an important role in improving perioperative pain control. This prospective, randomized, blinded, controlled clinical trial aimed to evaluate intraoperative isoflu...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-020-02303-9 |
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| author | Gabriel de O.L. Carapeba Isabela P. G. A. Nicácio Ana Beatriz F. Stelle Tatiane S. Bruno Gabriel M. Nicácio José S. Costa Júnior Rogerio Giuffrida Francisco J. Teixeira Neto Renata N. Cassu |
| author_facet | Gabriel de O.L. Carapeba Isabela P. G. A. Nicácio Ana Beatriz F. Stelle Tatiane S. Bruno Gabriel M. Nicácio José S. Costa Júnior Rogerio Giuffrida Francisco J. Teixeira Neto Renata N. Cassu |
| author_sort | Gabriel de O.L. Carapeba |
| collection | DOAJ |
| description | Abstract Background Infiltration of the surgical site with local anesthetics combined with nonsteroidal anti-inflammatory drugs may play an important role in improving perioperative pain control. This prospective, randomized, blinded, controlled clinical trial aimed to evaluate intraoperative isoflurane requirements, postoperative analgesia, and adverse events of infiltration of the surgical site with ropivacaine alone and combined with meloxicam in cats undergoing ovariohysterectomy. Forty-five cats premedicated with acepromazine/meperidine and anesthetized with propofol/isoflurane were randomly distributed into three treatments (n = 15 per group): physiological saline (group S), ropivacaine alone (1 mg/kg, group R) or combined with meloxicam (0.2 mg/kg, group RM) infiltrated at the surgical site (incision line, ovarian pedicles and uterus). End-tidal isoflurane concentration (FE’ISO), recorded at specific time points during surgery, was adjusted to inhibit autonomic responses to surgical stimulation. Pain was assessed using an Interactive Visual Analog Scale (IVAS), UNESP-Botucatu Multidimensional Composite Pain Scale (MCPS), and mechanical nociceptive thresholds (MNT) up to 24 h post-extubation. Rescue analgesia was provided with intramuscular morphine (0.1 mg/kg) when MCPS was ≥6. Results Area under the curve (AUC) of FE’ISO was significantly lower (P < 0.0001) in the RM (17.8 ± 3.1) compared to S (23.1 ± 2.2) and R groups (22.8 ± 1.1). Hypertension (systolic arterial pressure > 160 mmHg) coinciding with surgical manipulation was observed only in cats treated with S and R (4/15 cats, P = 0.08). The number of cats receiving rescue analgesia (4 cats in the S group and 1 cat in the R and RM groups) did not differ among groups (P = 0.17). The AUC of IVAS, MCPS and MNT did not differ among groups (P = 0.56, 0.64, and 0.18, respectively). Significantly lower IVAS pain scores were recorded at 1 h in the RM compared to the R and S groups (P = 0.021–0.018). There were no significant adverse effects during the study period. Conclusions Local infiltration with RM decreased intraoperative isoflurane requirements and resulted in some evidence of improved analgesia during the early postoperative period. Neither R nor RM infiltration appeared to result in long term analgesia in cats undergoing ovariohysterectomy. |
| first_indexed | 2024-12-10T06:56:31Z |
| format | Article |
| id | doaj.art-8ffd881c77014278ba90d5b59758e3d4 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-10T06:56:31Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-8ffd881c77014278ba90d5b59758e3d42022-12-22T01:58:25ZengBMCBMC Veterinary Research1746-61482020-03-0116111010.1186/s12917-020-02303-9Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomyGabriel de O.L. Carapeba0Isabela P. G. A. Nicácio1Ana Beatriz F. Stelle2Tatiane S. Bruno3Gabriel M. Nicácio4José S. Costa Júnior5Rogerio Giuffrida6Francisco J. Teixeira Neto7Renata N. Cassu8Postgraduate Program in Animal Science, Universidade do Oeste Paulista (UNOESTE)Postgraduate Program in Animal Science, Universidade do Oeste Paulista (UNOESTE)Department of Veterinary Surgery and Anesthesiology, Faculdade de Medicina Veterinária, Universidade do Oeste Paulista (UNOESTE)Department of Veterinary Surgery and Anesthesiology, Faculdade de Medicina Veterinária, Universidade do Oeste Paulista (UNOESTE)Department of Veterinary Surgery and Anesthesiology, Faculdade de Medicina Veterinária, Universidade do Oeste Paulista (UNOESTE)Department of Veterinary Surgery and Anesthesiology, Faculdade de Medicina Veterinária, Universidade do Oeste Paulista (UNOESTE)Postgraduate Program in Animal Science, Universidade do Oeste Paulista (UNOESTE)Department of Veterinary Surgery and Animal Reproduction, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista (UNESP)Postgraduate Program in Animal Science, Universidade do Oeste Paulista (UNOESTE)Abstract Background Infiltration of the surgical site with local anesthetics combined with nonsteroidal anti-inflammatory drugs may play an important role in improving perioperative pain control. This prospective, randomized, blinded, controlled clinical trial aimed to evaluate intraoperative isoflurane requirements, postoperative analgesia, and adverse events of infiltration of the surgical site with ropivacaine alone and combined with meloxicam in cats undergoing ovariohysterectomy. Forty-five cats premedicated with acepromazine/meperidine and anesthetized with propofol/isoflurane were randomly distributed into three treatments (n = 15 per group): physiological saline (group S), ropivacaine alone (1 mg/kg, group R) or combined with meloxicam (0.2 mg/kg, group RM) infiltrated at the surgical site (incision line, ovarian pedicles and uterus). End-tidal isoflurane concentration (FE’ISO), recorded at specific time points during surgery, was adjusted to inhibit autonomic responses to surgical stimulation. Pain was assessed using an Interactive Visual Analog Scale (IVAS), UNESP-Botucatu Multidimensional Composite Pain Scale (MCPS), and mechanical nociceptive thresholds (MNT) up to 24 h post-extubation. Rescue analgesia was provided with intramuscular morphine (0.1 mg/kg) when MCPS was ≥6. Results Area under the curve (AUC) of FE’ISO was significantly lower (P < 0.0001) in the RM (17.8 ± 3.1) compared to S (23.1 ± 2.2) and R groups (22.8 ± 1.1). Hypertension (systolic arterial pressure > 160 mmHg) coinciding with surgical manipulation was observed only in cats treated with S and R (4/15 cats, P = 0.08). The number of cats receiving rescue analgesia (4 cats in the S group and 1 cat in the R and RM groups) did not differ among groups (P = 0.17). The AUC of IVAS, MCPS and MNT did not differ among groups (P = 0.56, 0.64, and 0.18, respectively). Significantly lower IVAS pain scores were recorded at 1 h in the RM compared to the R and S groups (P = 0.021–0.018). There were no significant adverse effects during the study period. Conclusions Local infiltration with RM decreased intraoperative isoflurane requirements and resulted in some evidence of improved analgesia during the early postoperative period. Neither R nor RM infiltration appeared to result in long term analgesia in cats undergoing ovariohysterectomy.http://link.springer.com/article/10.1186/s12917-020-02303-9AnalgesiaFelineInfiltrationLocal anestheticNon-steroidal anti-inflammatory drug |
| spellingShingle | Gabriel de O.L. Carapeba Isabela P. G. A. Nicácio Ana Beatriz F. Stelle Tatiane S. Bruno Gabriel M. Nicácio José S. Costa Júnior Rogerio Giuffrida Francisco J. Teixeira Neto Renata N. Cassu Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy BMC Veterinary Research Analgesia Feline Infiltration Local anesthetic Non-steroidal anti-inflammatory drug |
| title | Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy |
| title_full | Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy |
| title_fullStr | Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy |
| title_full_unstemmed | Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy |
| title_short | Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy |
| title_sort | comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy |
| topic | Analgesia Feline Infiltration Local anesthetic Non-steroidal anti-inflammatory drug |
| url | http://link.springer.com/article/10.1186/s12917-020-02303-9 |
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