How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19?
(1) Background: The development of effective COVID-19 vaccines has reduced the impact of COVID-19 on the general population. Our study aims to analyze how vaccination modifies the likelihood of death and length of stay in hospitalized patients with COVID-19; (2) Methods: A retrospective cohort study...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/13/3905 |
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| author | Paloma Moreno-Nunez Aurora Bueno-Cavanillas Diego San Jose-Saras Jorge Vicente-Guijarro Abelardo Claudio Fernández Chávez Jesús María Aranaz-Andrés on behalf of Health Outcomes Research Group of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) |
| author_facet | Paloma Moreno-Nunez Aurora Bueno-Cavanillas Diego San Jose-Saras Jorge Vicente-Guijarro Abelardo Claudio Fernández Chávez Jesús María Aranaz-Andrés on behalf of Health Outcomes Research Group of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) |
| author_sort | Paloma Moreno-Nunez |
| collection | DOAJ |
| description | (1) Background: The development of effective COVID-19 vaccines has reduced the impact of COVID-19 on the general population. Our study aims to analyze how vaccination modifies the likelihood of death and length of stay in hospitalized patients with COVID-19; (2) Methods: A retrospective cohort study of 1927 hospitalized patients infected with COVID-19 was conducted. Information was gathered on vaccination status, hospitalization episode, and clinical profile of the patients. The effect of vaccination on mortality was analyzed using a multiple logistic regression model, and length of stay was analyzed using linear regression. The performance and fit of the models were evaluated; (3) Results: In hospitalized patients with COVID-19, the risk of dying during admission in vaccinated patients was half that of non-vaccinated (OR: 0.45; CI 95%: 0.25 to 0.84). In patients who were discharged due to improvement, the reduction in hospital stay in vaccinated patients was 3.17 days (CI 95%: 5.88 to 0.47); (4) Conclusions: Patients who, despite having been vaccinated, acquire the infection by SARS-CoV-2, have a significant reduction of the risk of death during admission and a reduction of hospital stay compared with unvaccinated patients. |
| first_indexed | 2024-03-09T10:27:21Z |
| format | Article |
| id | doaj.art-8fff5bef22654215a3bffed1a4d1047d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T10:27:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8fff5bef22654215a3bffed1a4d1047d2023-12-01T21:33:33ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011113390510.3390/jcm11133905How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19?Paloma Moreno-Nunez0Aurora Bueno-Cavanillas1Diego San Jose-Saras2Jorge Vicente-Guijarro3Abelardo Claudio Fernández Chávez4Jesús María Aranaz-Andrés5on behalf of Health Outcomes Research Group of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)Department of Preventive Medicine and Public Health, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainDepartment of Preventive Medicine and Public Health, Granada University, 18071 Granada, SpainDepartment of Preventive Medicine and Public Health, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainDepartment of Preventive Medicine and Public Health, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainDepartment of Preventive Medicine and Public Health, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainDepartment of Preventive Medicine and Public Health, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain(1) Background: The development of effective COVID-19 vaccines has reduced the impact of COVID-19 on the general population. Our study aims to analyze how vaccination modifies the likelihood of death and length of stay in hospitalized patients with COVID-19; (2) Methods: A retrospective cohort study of 1927 hospitalized patients infected with COVID-19 was conducted. Information was gathered on vaccination status, hospitalization episode, and clinical profile of the patients. The effect of vaccination on mortality was analyzed using a multiple logistic regression model, and length of stay was analyzed using linear regression. The performance and fit of the models were evaluated; (3) Results: In hospitalized patients with COVID-19, the risk of dying during admission in vaccinated patients was half that of non-vaccinated (OR: 0.45; CI 95%: 0.25 to 0.84). In patients who were discharged due to improvement, the reduction in hospital stay in vaccinated patients was 3.17 days (CI 95%: 5.88 to 0.47); (4) Conclusions: Patients who, despite having been vaccinated, acquire the infection by SARS-CoV-2, have a significant reduction of the risk of death during admission and a reduction of hospital stay compared with unvaccinated patients.https://www.mdpi.com/2077-0383/11/13/3905COVID-19 vaccinesvaccine effectivenesshospital mortalitycritical carehospitalisation |
| spellingShingle | Paloma Moreno-Nunez Aurora Bueno-Cavanillas Diego San Jose-Saras Jorge Vicente-Guijarro Abelardo Claudio Fernández Chávez Jesús María Aranaz-Andrés on behalf of Health Outcomes Research Group of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19? Journal of Clinical Medicine COVID-19 vaccines vaccine effectiveness hospital mortality critical care hospitalisation |
| title | How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19? |
| title_full | How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19? |
| title_fullStr | How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19? |
| title_full_unstemmed | How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19? |
| title_short | How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19? |
| title_sort | how does vaccination against sars cov 2 affect hospitalized patients with covid 19 |
| topic | COVID-19 vaccines vaccine effectiveness hospital mortality critical care hospitalisation |
| url | https://www.mdpi.com/2077-0383/11/13/3905 |
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