Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery
A mesoporous silica-based drug delivery system (MS@PNIPAm-PAAm NPs) was synthesized by conjugating the PNIPAm-PAAm copolymer onto the mesoporous silica (MS) surface as a gatekeeper that responds to temperature and pH changes. The drug delivery studies are carried out in vitro at different pH (7.4, 6...
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MDPI AG
2023-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/3/795 |
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| author | Kokila Thirupathi Madhappan Santhamoorthy Sivaprakasam Radhakrishnan Selvakumari Ulagesan Taek-Jeong Nam Thi Tuong Vy Phan Seong-Cheol Kim |
| author_facet | Kokila Thirupathi Madhappan Santhamoorthy Sivaprakasam Radhakrishnan Selvakumari Ulagesan Taek-Jeong Nam Thi Tuong Vy Phan Seong-Cheol Kim |
| author_sort | Kokila Thirupathi |
| collection | DOAJ |
| description | A mesoporous silica-based drug delivery system (MS@PNIPAm-PAAm NPs) was synthesized by conjugating the PNIPAm-PAAm copolymer onto the mesoporous silica (MS) surface as a gatekeeper that responds to temperature and pH changes. The drug delivery studies are carried out in vitro at different pH (7.4, 6.5, and 5.0) and temperatures (such as 25 °C and 42 °C, respectively). The surface conjugated copolymer (PNIPAm-PAAm) acts as a gatekeeper below the lower critical solution temperature (LCST) (<32 °C) and as a collapsed globule structure above LCST (>32 °C), resulting in controlled drug delivery from the MS@PNIPAm-PAAm system. Furthermore, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cellular internalization results support the prepared MS@PNIPAm-PAAm NPs being biocompatible and readily taken up by MDA-MB-231 cells. The prepared MS@PNIPAm-PAAm NPs, with their pH-responsive drug release behavior and good biocompatibility, could be used as a drug delivery vehicle where sustained drug release at higher temperatures is required. |
| first_indexed | 2024-03-11T06:02:23Z |
| format | Article |
| id | doaj.art-8fff82328ddc4979b36f9c3e0e8f1112 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:02:23Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8fff82328ddc4979b36f9c3e0e8f11122023-11-17T13:14:29ZengMDPI AGPharmaceutics1999-49232023-02-0115379510.3390/pharmaceutics15030795Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug DeliveryKokila Thirupathi0Madhappan Santhamoorthy1Sivaprakasam Radhakrishnan2Selvakumari Ulagesan3Taek-Jeong Nam4Thi Tuong Vy Phan5Seong-Cheol Kim6Department of Physics, Government Arts and Science College for Women, Karimangalam, Dharmapuri 635111, Tamil Nadu, IndiaSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of KoreaDepartment of Organic Materials and Fiber Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si 54896, Republic of KoreaDivision of Fisheries Life Sciences, Pukyong National University, Nam-gu, Busan 48513, Republic of KoreaInstitute of Fisheries Sciences, Pukyong National University, Gijang-gun, Busan 46041, Republic of KoreaCenter for Advanced Chemistry, Institute of Research and Development, Duy Tan University, 03 Quang Trung, Hai Chau, Danang 550000, VietnamSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of KoreaA mesoporous silica-based drug delivery system (MS@PNIPAm-PAAm NPs) was synthesized by conjugating the PNIPAm-PAAm copolymer onto the mesoporous silica (MS) surface as a gatekeeper that responds to temperature and pH changes. The drug delivery studies are carried out in vitro at different pH (7.4, 6.5, and 5.0) and temperatures (such as 25 °C and 42 °C, respectively). The surface conjugated copolymer (PNIPAm-PAAm) acts as a gatekeeper below the lower critical solution temperature (LCST) (<32 °C) and as a collapsed globule structure above LCST (>32 °C), resulting in controlled drug delivery from the MS@PNIPAm-PAAm system. Furthermore, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cellular internalization results support the prepared MS@PNIPAm-PAAm NPs being biocompatible and readily taken up by MDA-MB-231 cells. The prepared MS@PNIPAm-PAAm NPs, with their pH-responsive drug release behavior and good biocompatibility, could be used as a drug delivery vehicle where sustained drug release at higher temperatures is required.https://www.mdpi.com/1999-4923/15/3/795mesoporous silicadrug deliverythermosensitive copolymerpH-stimulibiocompatibility |
| spellingShingle | Kokila Thirupathi Madhappan Santhamoorthy Sivaprakasam Radhakrishnan Selvakumari Ulagesan Taek-Jeong Nam Thi Tuong Vy Phan Seong-Cheol Kim Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery Pharmaceutics mesoporous silica drug delivery thermosensitive copolymer pH-stimuli biocompatibility |
| title | Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery |
| title_full | Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery |
| title_fullStr | Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery |
| title_full_unstemmed | Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery |
| title_short | Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery |
| title_sort | thermosensitive polymer modified mesoporous silica for ph and temperature responsive drug delivery |
| topic | mesoporous silica drug delivery thermosensitive copolymer pH-stimuli biocompatibility |
| url | https://www.mdpi.com/1999-4923/15/3/795 |
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