Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery

Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery

A mesoporous silica-based drug delivery system (MS@PNIPAm-PAAm NPs) was synthesized by conjugating the PNIPAm-PAAm copolymer onto the mesoporous silica (MS) surface as a gatekeeper that responds to temperature and pH changes. The drug delivery studies are carried out in vitro at different pH (7.4, 6...

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Bibliographic Details
Main Authors: Kokila Thirupathi, Madhappan Santhamoorthy, Sivaprakasam Radhakrishnan, Selvakumari Ulagesan, Taek-Jeong Nam, Thi Tuong Vy Phan, Seong-Cheol Kim
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
mesoporous silica
drug delivery
thermosensitive copolymer
pH-stimuli
biocompatibility
Online Access:https://www.mdpi.com/1999-4923/15/3/795

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