LPCAT2 controls chemoresistance in colorectal cancer
Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1448245 |
| _version_ | 1797677155722723328 |
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| author | Alexia Karen Cotte Virginie Aires François Ghiringhelli Dominique Delmas |
| author_facet | Alexia Karen Cotte Virginie Aires François Ghiringhelli Dominique Delmas |
| author_sort | Alexia Karen Cotte |
| collection | DOAJ |
| description | Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation. |
| first_indexed | 2024-03-11T22:40:56Z |
| format | Article |
| id | doaj.art-9000032af48e4fccb395f82ac04468d6 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:56Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-9000032af48e4fccb395f82ac04468d62023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-05-015310.1080/23723556.2018.14482451448245LPCAT2 controls chemoresistance in colorectal cancerAlexia Karen Cotte0Virginie Aires1François Ghiringhelli2Dominique Delmas3University of Bourgogne-Franche ComtéUniversity of Bourgogne-Franche ComtéUniversity of Bourgogne-Franche ComtéUniversity of Bourgogne-Franche ComtéLipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.http://dx.doi.org/10.1080/23723556.2018.1448245colorectal cancerchemoresistanceimmunogenic cell deathlipid dropletslpcat2 |
| spellingShingle | Alexia Karen Cotte Virginie Aires François Ghiringhelli Dominique Delmas LPCAT2 controls chemoresistance in colorectal cancer Molecular & Cellular Oncology colorectal cancer chemoresistance immunogenic cell death lipid droplets lpcat2 |
| title | LPCAT2 controls chemoresistance in colorectal cancer |
| title_full | LPCAT2 controls chemoresistance in colorectal cancer |
| title_fullStr | LPCAT2 controls chemoresistance in colorectal cancer |
| title_full_unstemmed | LPCAT2 controls chemoresistance in colorectal cancer |
| title_short | LPCAT2 controls chemoresistance in colorectal cancer |
| title_sort | lpcat2 controls chemoresistance in colorectal cancer |
| topic | colorectal cancer chemoresistance immunogenic cell death lipid droplets lpcat2 |
| url | http://dx.doi.org/10.1080/23723556.2018.1448245 |
| work_keys_str_mv | AT alexiakarencotte lpcat2controlschemoresistanceincolorectalcancer AT virginieaires lpcat2controlschemoresistanceincolorectalcancer AT francoisghiringhelli lpcat2controlschemoresistanceincolorectalcancer AT dominiquedelmas lpcat2controlschemoresistanceincolorectalcancer |