Cancer vaccines based on whole-tumor lysate or neoepitopes with validated HLA binding outperform those with predicted HLA-binding affinity
Summary: Antigen selection and prioritization represent crucial determinants of vaccines’ efficacy. Here, we compare two personalized dendritic cell-based vaccination strategies using whole-tumor lysate or neoantigens. Data in mouse and in cancer patients demonstrate that peptide vaccines using neoa...
Full description
Bibliographic Details
| Main Authors: |
Hajer Fritah,
Michele Graciotti,
Cheryl Lai-Lai Chiang,
Anne-Laure Huguenin- Bergenat,
Rémy Petremand,
Ritaparna Ahmed,
Philippe Guillaume,
Julien Schmidt,
Brian J. Stevenson,
David Gfeller,
Alexandre Harari,
Lana E. Kandalaft |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Elsevier
2023-04-01
|
|---|
| Series: | iScience
|
|---|
| Subjects: | |
|---|
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223003656
|
|---|