Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis
Metastases are responsible for the vast majority of cancer deaths, yet most therapeutic efforts have focused on targeting and interrupting tumor growth rather than impairing the metastatic process. Traditionally, cancer metastasis is attributed to the dissemination of neoplastic cells from the prima...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/12/1566 |
| _version_ | 1797595605147582464 |
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| author | Goffredo O. Arena Stefano Forte Mohamed Abdouh Cheryl Vanier Denis Corbeil Aurelio Lorico |
| author_facet | Goffredo O. Arena Stefano Forte Mohamed Abdouh Cheryl Vanier Denis Corbeil Aurelio Lorico |
| author_sort | Goffredo O. Arena |
| collection | DOAJ |
| description | Metastases are responsible for the vast majority of cancer deaths, yet most therapeutic efforts have focused on targeting and interrupting tumor growth rather than impairing the metastatic process. Traditionally, cancer metastasis is attributed to the dissemination of neoplastic cells from the primary tumor to distant organs through blood and lymphatic circulation. A thorough understanding of the metastatic process is essential to develop new therapeutic strategies that improve cancer survival. Since Paget’s original description of the “Seed and Soil” hypothesis over a hundred years ago, alternative theories and new players have been proposed. In particular, the role of extracellular vesicles (EVs) released by cancer cells and their uptake by neighboring cells or at distinct anatomical sites has been explored. Here, we will outline and discuss these alternative theories and emphasize the horizontal transfer of EV-associated biomolecules as a possibly major event leading to cell transformation and the induction of metastases. We will also highlight the recently discovered intracellular pathway used by EVs to deliver their cargoes into the nucleus of recipient cells, which is a potential target for novel anti-metastatic strategies. |
| first_indexed | 2024-03-11T02:38:58Z |
| format | Article |
| id | doaj.art-9001c506745b453d8a9bf543d4bf3acb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T02:38:58Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9001c506745b453d8a9bf543d4bf3acb2023-11-18T09:42:49ZengMDPI AGCells2073-44092023-06-011212156610.3390/cells12121566Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in MetastasisGoffredo O. Arena0Stefano Forte1Mohamed Abdouh2Cheryl Vanier3Denis Corbeil4Aurelio Lorico5Department of Surgery, McGill University, Montréal, QC H3A 0G4, CanadaMediterranean Institute of Oncology, 95029 Viagrande, ItalyCancer Research Program, Research Institute, McGill University Health Centre, Montréal, QC H3A 0G4, CanadaTouro University Nevada College of Medicine, Henderson, NV 89014, USABiotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, 01307 Dresden, GermanyMediterranean Institute of Oncology, 95029 Viagrande, ItalyMetastases are responsible for the vast majority of cancer deaths, yet most therapeutic efforts have focused on targeting and interrupting tumor growth rather than impairing the metastatic process. Traditionally, cancer metastasis is attributed to the dissemination of neoplastic cells from the primary tumor to distant organs through blood and lymphatic circulation. A thorough understanding of the metastatic process is essential to develop new therapeutic strategies that improve cancer survival. Since Paget’s original description of the “Seed and Soil” hypothesis over a hundred years ago, alternative theories and new players have been proposed. In particular, the role of extracellular vesicles (EVs) released by cancer cells and their uptake by neighboring cells or at distinct anatomical sites has been explored. Here, we will outline and discuss these alternative theories and emphasize the horizontal transfer of EV-associated biomolecules as a possibly major event leading to cell transformation and the induction of metastases. We will also highlight the recently discovered intracellular pathway used by EVs to deliver their cargoes into the nucleus of recipient cells, which is a potential target for novel anti-metastatic strategies.https://www.mdpi.com/2073-4409/12/12/1566cancermetastasisnucleoplasmic reticulumextracellular vesiclesexosomesoncogene |
| spellingShingle | Goffredo O. Arena Stefano Forte Mohamed Abdouh Cheryl Vanier Denis Corbeil Aurelio Lorico Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis Cells cancer metastasis nucleoplasmic reticulum extracellular vesicles exosomes oncogene |
| title | Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis |
| title_full | Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis |
| title_fullStr | Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis |
| title_full_unstemmed | Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis |
| title_short | Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis |
| title_sort | horizontal transfer of malignant traits and the involvement of extracellular vesicles in metastasis |
| topic | cancer metastasis nucleoplasmic reticulum extracellular vesicles exosomes oncogene |
| url | https://www.mdpi.com/2073-4409/12/12/1566 |
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