Characterisation of a Novel Anti-CD52 Antibody with Improved Efficacy and Reduced Immunogenicity.
Anti-CD52 therapy has been shown to be effective in the treatment of a number of B cell malignancies, hematopoietic disorders and autoimmune diseases (including rheumatoid arthritis and multiple sclerosis); however the current standard of treatment, the humanized monoclonal antibody alemtuzumab, is...
Main Authors: | Robert G E Holgate, Richard Weldon, Timothy D Jones, Matthew P Baker |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4570798?pdf=render |
Similar Items
-
Engineering an anti-CD52 antibody for enhanced deamidation stability
by: Huawei Qiu, et al.
Published: (2019-10-01) -
Anti-CD25 antibody enhancement of vaccine-induced immunogenicity: increased durable cellular immunity with reduced immunodominance.
by: Moore, A, et al.
Published: (2005) -
Anti-Drug Antibodies: Emerging Approaches to Predict, Reduce or Reverse Biotherapeutic Immunogenicity
by: Kathleen P. Pratt
Published: (2018-05-01) -
Effect of anti-CD52 antibody alemtuzumab on <it>ex-vivo </it>culture of umbilical cord blood stem cells
by: Law Ping, et al.
Published: (2008-10-01) -
Autografting with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukemia.
by: Treleaven, J, et al.
Published: (1996)