Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives
Gemma Camiña-Conforto, Laura Mateu-Arrom, Anna López-Ferrer, Lluís Puig Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainCorrespondence: Gemma Camiña-Conforto, Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, Bloque A, 5a planta (secr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | Patient Preference and Adherence |
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| Online Access: | https://www.dovepress.com/bimekizumab-in-the-treatment-of-plaque-psoriasis-focus-on-patient-sele-peer-reviewed-fulltext-article-PPA |
| _version_ | 1797789367562928128 |
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| author | Camiña-Conforto G Mateu-Arrom L López-Ferrer A Puig L |
| author_facet | Camiña-Conforto G Mateu-Arrom L López-Ferrer A Puig L |
| author_sort | Camiña-Conforto G |
| collection | DOAJ |
| description | Gemma Camiña-Conforto, Laura Mateu-Arrom, Anna López-Ferrer, Lluís Puig Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainCorrespondence: Gemma Camiña-Conforto, Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, Bloque A, 5a planta (secretaria Dermatología), Barcelona, 08041, Spain, Tel +34 93 553 7007, Fax +34 93 553 7008, Email gcamina@santpau.catAbstract: Psoriasis is a chronic systemic inflammatory disease that significatively impairs patients’ quality of life. Biological treatments are highly effective and safe and have led to breakthroughs in the management of patients with moderate-to-severe psoriasis. However, therapeutic response can be unsatisfactory or lost with time, leading to discontinuation of treatment. Bimekizumab is a humanized monoclonal antibody that specifically inhibits both interleukin (IL)-17A and IL-17F. The efficacy and safety of bimekizumab in moderate-to-severe plaque psoriasis has been demonstrated in Phase 2 and Phase 3 clinical trials. Bimekizumab may offer some advantages over other biological treatments, making it especially indicated for certain patients. This narrative review aims to summarize the latest published evidence on the use of bimekizumab for the treatment of moderate-severe plaque psoriasis, focusing on patient selection and therapeutic perspectives. Bimekizumab has been shown to be more efficacious than adalimumab, secukinumab and ustekinumab in clinical trials, with high estimated probabilities of achieving complete (approximately 60%) or almost complete clearance (approximately 85%) of psoriasis at weeks 10– 16, and a good safety profile. Response to bimekizumab is usually fast and maintained in the long term for both biologic-naive patients and those resistant to previous biologic treatments. The usual maintenance dose of 320 mg every 8 weeks makes bimekizumab especially convenient for non-compliant patients. Moreover, the efficacy and safety of bimekizumab have also been demonstrated in psoriasis affecting challenging-to-treat areas, psoriatic arthritis and hidradenitis suppurativa. In conclusion, dual inhibition of IL-17A and IL-17F with bimekizumab is a good therapeutic option for moderate-to-severe psoriasis.Keywords: psoriasis, bimekizumab, patient selection, interleukin-17, patient compliance, biological therapy |
| first_indexed | 2024-03-13T01:49:43Z |
| format | Article |
| id | doaj.art-900431e091c341c0b1a4baadf046f0d1 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-03-13T01:49:43Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-900431e091c341c0b1a4baadf046f0d12023-07-02T19:49:18ZengDove Medical PressPatient Preference and Adherence1177-889X2023-06-01Volume 171541154984813Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and PerspectivesCamiña-Conforto GMateu-Arrom LLópez-Ferrer APuig LGemma Camiña-Conforto, Laura Mateu-Arrom, Anna López-Ferrer, Lluís Puig Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainCorrespondence: Gemma Camiña-Conforto, Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, Bloque A, 5a planta (secretaria Dermatología), Barcelona, 08041, Spain, Tel +34 93 553 7007, Fax +34 93 553 7008, Email gcamina@santpau.catAbstract: Psoriasis is a chronic systemic inflammatory disease that significatively impairs patients’ quality of life. Biological treatments are highly effective and safe and have led to breakthroughs in the management of patients with moderate-to-severe psoriasis. However, therapeutic response can be unsatisfactory or lost with time, leading to discontinuation of treatment. Bimekizumab is a humanized monoclonal antibody that specifically inhibits both interleukin (IL)-17A and IL-17F. The efficacy and safety of bimekizumab in moderate-to-severe plaque psoriasis has been demonstrated in Phase 2 and Phase 3 clinical trials. Bimekizumab may offer some advantages over other biological treatments, making it especially indicated for certain patients. This narrative review aims to summarize the latest published evidence on the use of bimekizumab for the treatment of moderate-severe plaque psoriasis, focusing on patient selection and therapeutic perspectives. Bimekizumab has been shown to be more efficacious than adalimumab, secukinumab and ustekinumab in clinical trials, with high estimated probabilities of achieving complete (approximately 60%) or almost complete clearance (approximately 85%) of psoriasis at weeks 10– 16, and a good safety profile. Response to bimekizumab is usually fast and maintained in the long term for both biologic-naive patients and those resistant to previous biologic treatments. The usual maintenance dose of 320 mg every 8 weeks makes bimekizumab especially convenient for non-compliant patients. Moreover, the efficacy and safety of bimekizumab have also been demonstrated in psoriasis affecting challenging-to-treat areas, psoriatic arthritis and hidradenitis suppurativa. In conclusion, dual inhibition of IL-17A and IL-17F with bimekizumab is a good therapeutic option for moderate-to-severe psoriasis.Keywords: psoriasis, bimekizumab, patient selection, interleukin-17, patient compliance, biological therapyhttps://www.dovepress.com/bimekizumab-in-the-treatment-of-plaque-psoriasis-focus-on-patient-sele-peer-reviewed-fulltext-article-PPApsoriasisbimekizumabpatient selectioninterleukin-17patient compliancebiological therapy |
| spellingShingle | Camiña-Conforto G Mateu-Arrom L López-Ferrer A Puig L Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives Patient Preference and Adherence psoriasis bimekizumab patient selection interleukin-17 patient compliance biological therapy |
| title | Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives |
| title_full | Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives |
| title_fullStr | Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives |
| title_full_unstemmed | Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives |
| title_short | Bimekizumab in the Treatment of Plaque Psoriasis: Focus on Patient Selection and Perspectives |
| title_sort | bimekizumab in the treatment of plaque psoriasis focus on patient selection and perspectives |
| topic | psoriasis bimekizumab patient selection interleukin-17 patient compliance biological therapy |
| url | https://www.dovepress.com/bimekizumab-in-the-treatment-of-plaque-psoriasis-focus-on-patient-sele-peer-reviewed-fulltext-article-PPA |
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