Case Report: Can Inhaled Adenosine Attenuate COVID-19?
This case report demonstrates a small repetition of the case series carried out in Italy wherein inhaled adenosine was administered to patients experiencing severe and worsening coronavirus disease-2019 (COVID-19). The two cases are important not only because they were the first of their type in the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.676577/full |
| _version_ | 1819112258197782528 |
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| author | Bruce D. Spiess Michael Sitkovsky Pierpaolo Correale Nikolaus Gravenstein Cynthia Garvan Timothy E. Morey Brenda G. Fahy Leslie Hendeles Thomas J. Pliura Thomas D. Martin Velyn Wu Corey Astrom Danielle S. Nelson |
| author_facet | Bruce D. Spiess Michael Sitkovsky Pierpaolo Correale Nikolaus Gravenstein Cynthia Garvan Timothy E. Morey Brenda G. Fahy Leslie Hendeles Thomas J. Pliura Thomas D. Martin Velyn Wu Corey Astrom Danielle S. Nelson |
| author_sort | Bruce D. Spiess |
| collection | DOAJ |
| description | This case report demonstrates a small repetition of the case series carried out in Italy wherein inhaled adenosine was administered to patients experiencing severe and worsening coronavirus disease-2019 (COVID-19). The two cases are important not only because they were the first of their type in the United States, but also because both patients were DNR/DNI and were therefore expected to die. Study repetition is vitally important in medicine. New work in pharmacology hypothesizes that adenosine-regulator proteins may play a role in the pathogenesis of COVID-19 infection. Furthermore, adenosine, by interacting with cell receptor sites, has pluripotent effects upon inflammatory cells, is anti-inflammatory, and is important in tissue hypoxia signaling. Inhaled adenosine is potentially safe; thousands have received it for asthmatic challenge testing. The effects of adenosine in these two cases were rapid, positive, and fit the pharmacologic hypotheses (as seen in prior work in this journal) and support its role as a therapeutic nucleoside. |
| first_indexed | 2024-12-22T04:10:39Z |
| format | Article |
| id | doaj.art-9004a3edbcd44277891d44a1fecd9539 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T04:10:39Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-9004a3edbcd44277891d44a1fecd95392022-12-21T18:39:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-08-011210.3389/fphar.2021.676577676577Case Report: Can Inhaled Adenosine Attenuate COVID-19?Bruce D. Spiess0Michael Sitkovsky1Pierpaolo Correale2Nikolaus Gravenstein3Cynthia Garvan4Timothy E. Morey5Brenda G. Fahy6Leslie Hendeles7Thomas J. Pliura8Thomas D. Martin9Velyn Wu10Corey Astrom11Danielle S. Nelson12Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United StatesNew England Inflammation and Tissue Protection Institute - Northeastern University, Boston, MA, United StatesMedical Oncology Unit, Covid19 Scientific Task Force, Grand Metropolitan Hospital, Reggio Calabria, ItalyDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United StatesDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United StatesDepartment of Anesthesiology, University of Florida School of Medicine, Gainesville, FL, United StatesDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United StatesCollege of Pharmacy, University of Florida, Gainesville, FL, United StatesPrivate Practice Emergency Department, Champaign, IL, United StatesDepartment of Surgery (Cardiac Surgery), University of Florida School of Medicine, Gainesville, FL, United StatesDepartment of Community Health and Family Medicine, University of Florida, College of Medicine, Gainesville, FL, United StatesDepartment of Anesthesiology, University of Florida School of Medicine, Gainesville, FL, United StatesDepartment of Community Health and Family Medicine, University of Florida, College of Medicine, Gainesville, FL, United StatesThis case report demonstrates a small repetition of the case series carried out in Italy wherein inhaled adenosine was administered to patients experiencing severe and worsening coronavirus disease-2019 (COVID-19). The two cases are important not only because they were the first of their type in the United States, but also because both patients were DNR/DNI and were therefore expected to die. Study repetition is vitally important in medicine. New work in pharmacology hypothesizes that adenosine-regulator proteins may play a role in the pathogenesis of COVID-19 infection. Furthermore, adenosine, by interacting with cell receptor sites, has pluripotent effects upon inflammatory cells, is anti-inflammatory, and is important in tissue hypoxia signaling. Inhaled adenosine is potentially safe; thousands have received it for asthmatic challenge testing. The effects of adenosine in these two cases were rapid, positive, and fit the pharmacologic hypotheses (as seen in prior work in this journal) and support its role as a therapeutic nucleoside.https://www.frontiersin.org/articles/10.3389/fphar.2021.676577/fullCOVID-19acute respiratory distress syndromeARDSnebulizeradenosinecase report |
| spellingShingle | Bruce D. Spiess Michael Sitkovsky Pierpaolo Correale Nikolaus Gravenstein Cynthia Garvan Timothy E. Morey Brenda G. Fahy Leslie Hendeles Thomas J. Pliura Thomas D. Martin Velyn Wu Corey Astrom Danielle S. Nelson Case Report: Can Inhaled Adenosine Attenuate COVID-19? Frontiers in Pharmacology COVID-19 acute respiratory distress syndrome ARDS nebulizer adenosine case report |
| title | Case Report: Can Inhaled Adenosine Attenuate COVID-19? |
| title_full | Case Report: Can Inhaled Adenosine Attenuate COVID-19? |
| title_fullStr | Case Report: Can Inhaled Adenosine Attenuate COVID-19? |
| title_full_unstemmed | Case Report: Can Inhaled Adenosine Attenuate COVID-19? |
| title_short | Case Report: Can Inhaled Adenosine Attenuate COVID-19? |
| title_sort | case report can inhaled adenosine attenuate covid 19 |
| topic | COVID-19 acute respiratory distress syndrome ARDS nebulizer adenosine case report |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.676577/full |
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