Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22)
The English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) antimicrobial resistance (AMR) chapter reports on bacterial, viral, and fungal AMR trends between 2017 and 2021 in England. A 10.8% increase in patient episodes of bacteraemia or fungaemia was observed, and the...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Medical Sciences Forum |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-9992/15/1/3 |
| _version_ | 1797379859268239360 |
|---|---|
| author | Rebecca Guy Hannah Higgins Jamie Rudman Holly Fountain Kirsty F. Bennet Katie L. Hopkins Alicia Demirjian Sarah M. Gerver Mariyam Mirfenderesky Katherine L. Henderson |
| author_facet | Rebecca Guy Hannah Higgins Jamie Rudman Holly Fountain Kirsty F. Bennet Katie L. Hopkins Alicia Demirjian Sarah M. Gerver Mariyam Mirfenderesky Katherine L. Henderson |
| author_sort | Rebecca Guy |
| collection | DOAJ |
| description | The English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) antimicrobial resistance (AMR) chapter reports on bacterial, viral, and fungal AMR trends between 2017 and 2021 in England. A 10.8% increase in patient episodes of bacteraemia or fungaemia was observed, and the estimated burden of resistance decreased by 4.2%. Individuals with an antimicrobial-resistant strain (resistant to ≥1 key AMR burden-defined antibiotics) had a higher crude case fatality rate (18.1%) compared to those with a susceptible strain (16.3%). The effect of deprivation on carbapenemase-producing organisms (CPO) incidence, and the impact of the AMR burden across ethnic groups, have been described for the first time. Understanding the impact of ethnicity, deprivation, regional divergence, and potential confounders remains a crucial avenue of enquiry to target appropriate AMR interventions. These findings were presented at the ESPAUR Report webinar on 23 November 2022. |
| first_indexed | 2024-03-08T20:30:06Z |
| format | Article |
| id | doaj.art-90082b2e418648c6ab5978edebe64f05 |
| institution | Directory Open Access Journal |
| issn | 2673-9992 |
| language | English |
| last_indexed | 2024-03-08T20:30:06Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences Forum |
| spelling | doaj.art-90082b2e418648c6ab5978edebe64f052023-12-22T14:28:14ZengMDPI AGMedical Sciences Forum2673-99922023-03-01151310.3390/msf2022015003Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22)Rebecca Guy0Hannah Higgins1Jamie Rudman2Holly Fountain3Kirsty F. Bennet4Katie L. Hopkins5Alicia Demirjian6Sarah M. Gerver7Mariyam Mirfenderesky8Katherine L. Henderson9Healthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKHealthcare-Associated Infections, Fungal, Antimicrobial Resistance, Antimicrobial Usage and Sepsis Division, United Kingdom Health Security Agency (UKHSA), London NW9 5EQ, UKThe English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) antimicrobial resistance (AMR) chapter reports on bacterial, viral, and fungal AMR trends between 2017 and 2021 in England. A 10.8% increase in patient episodes of bacteraemia or fungaemia was observed, and the estimated burden of resistance decreased by 4.2%. Individuals with an antimicrobial-resistant strain (resistant to ≥1 key AMR burden-defined antibiotics) had a higher crude case fatality rate (18.1%) compared to those with a susceptible strain (16.3%). The effect of deprivation on carbapenemase-producing organisms (CPO) incidence, and the impact of the AMR burden across ethnic groups, have been described for the first time. Understanding the impact of ethnicity, deprivation, regional divergence, and potential confounders remains a crucial avenue of enquiry to target appropriate AMR interventions. These findings were presented at the ESPAUR Report webinar on 23 November 2022.https://www.mdpi.com/2673-9992/15/1/3antimicrobialresistanceEnglandbacterialfungalviral |
| spellingShingle | Rebecca Guy Hannah Higgins Jamie Rudman Holly Fountain Kirsty F. Bennet Katie L. Hopkins Alicia Demirjian Sarah M. Gerver Mariyam Mirfenderesky Katherine L. Henderson Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22) Medical Sciences Forum antimicrobial resistance England bacterial fungal viral |
| title | Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22) |
| title_full | Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22) |
| title_fullStr | Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22) |
| title_full_unstemmed | Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22) |
| title_short | Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22) |
| title_sort | antimicrobial resistance in england 2017 to 2021 espaur report 2021 22 |
| topic | antimicrobial resistance England bacterial fungal viral |
| url | https://www.mdpi.com/2673-9992/15/1/3 |
| work_keys_str_mv | AT rebeccaguy antimicrobialresistanceinengland2017to2021espaurreport202122 AT hannahhiggins antimicrobialresistanceinengland2017to2021espaurreport202122 AT jamierudman antimicrobialresistanceinengland2017to2021espaurreport202122 AT hollyfountain antimicrobialresistanceinengland2017to2021espaurreport202122 AT kirstyfbennet antimicrobialresistanceinengland2017to2021espaurreport202122 AT katielhopkins antimicrobialresistanceinengland2017to2021espaurreport202122 AT aliciademirjian antimicrobialresistanceinengland2017to2021espaurreport202122 AT sarahmgerver antimicrobialresistanceinengland2017to2021espaurreport202122 AT mariyammirfenderesky antimicrobialresistanceinengland2017to2021espaurreport202122 AT katherinelhenderson antimicrobialresistanceinengland2017to2021espaurreport202122 |