Spondyloarthritis; clinical manifestations and evaluation of response to treatment in Iran
Introduction: Spondyloarthropathies (SpAs) are inflammatory diseases with symptoms such as spinal pain, sacroiliac, and peripheral involvement. The prevalence of SpAs is reported from 0.2% to 1.6%. SpAs can cause significant disabilities for patients. Its medical treatment is mainly with non-steroid...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Diabetic Nephropathy Prevention
2022-07-01
|
| Series: | Journal of Preventive Epidemiology |
| Subjects: | |
| Online Access: | https://jprevepi.com/PDF/jpe-7-e23162.pdf |
| _version_ | 1797990661662703616 |
|---|---|
| author | Seyed Mohammad Hashem Montazeri Seyed Mojtaba Alavi Fatemeh Radmard Maryam Masoumi Mostafa Vahedian |
| author_facet | Seyed Mohammad Hashem Montazeri Seyed Mojtaba Alavi Fatemeh Radmard Maryam Masoumi Mostafa Vahedian |
| author_sort | Seyed Mohammad Hashem Montazeri |
| collection | DOAJ |
| description | Introduction: Spondyloarthropathies (SpAs) are inflammatory diseases with symptoms such as spinal pain, sacroiliac, and peripheral involvement. The prevalence of SpAs is reported from 0.2% to 1.6%. SpAs can cause significant disabilities for patients. Its medical treatment is mainly with non-steroidal anti-inflammatory (NSAIDs) and anti-TNF drugs. Objectives: The primary purpose of this study is to carefully detect the clinical manifestations of patients, demographic characteristics, and the effectiveness of common medications in this disease. Patients and Methods: The present study is a retrospective descriptive study. The statistical population is 101 patients with SpA who have demographic information and items related to clinical conditions, radiographic findings and response to treatment. Results: One hundred one patients with SpA [46 (45.5%) female] with the age of 36.83± 10.45 years were studied. Around 66 patients (64.7%) had ankylosing spondylitis (AS), with the highest prevalence of AS. The most common clinical symptoms in patients were axial and peripheral/ extra-articular symptoms. The response to patients’ treatment were 61 patients (60.4%) had responded to the first stage of treatment, since only one patient needed to change the treatment steps in five times. Conclusion: We found, most patients with SpA were young patients. The most common radiological finding was Sacroiliitis. The most common clinical finding was extra-articular manifestations. Peripheral manifestations of the disease in women and axial images in men were common. The highest response to treatment was observed with the combination of indomethacin, sulfasalazine (SSZ) and indomethacin (alone). |
| first_indexed | 2024-04-11T08:39:59Z |
| format | Article |
| id | doaj.art-900922bd1c9744dda37f48bc1322c662 |
| institution | Directory Open Access Journal |
| issn | 2476-3934 |
| language | English |
| last_indexed | 2024-04-11T08:39:59Z |
| publishDate | 2022-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Preventive Epidemiology |
| spelling | doaj.art-900922bd1c9744dda37f48bc1322c6622022-12-22T04:34:14ZengSociety of Diabetic Nephropathy PreventionJournal of Preventive Epidemiology2476-39342022-07-0172e23162e2316210.34172/jpe.2022.23162jpe-23162Spondyloarthritis; clinical manifestations and evaluation of response to treatment in IranSeyed Mohammad Hashem Montazeri0Seyed Mojtaba Alavi1Fatemeh Radmard2Maryam Masoumi3Mostafa Vahedian4Clinical Research and Development Center, Qom University of Medical Sciences, Qom, IranClinical Research and Development Center, Qom University of Medical Sciences, Qom, IranClinical Research and Development Center, Qom University of Medical Sciences, Qom, IranClinical Research and Development Center, Qom University of Medical Sciences, Qom, IranDepartment of Biostatistics and Epidemiology, Neuroscience Research Center, School of Medicine, Qom University of Medical Sciences, Qom, IranIntroduction: Spondyloarthropathies (SpAs) are inflammatory diseases with symptoms such as spinal pain, sacroiliac, and peripheral involvement. The prevalence of SpAs is reported from 0.2% to 1.6%. SpAs can cause significant disabilities for patients. Its medical treatment is mainly with non-steroidal anti-inflammatory (NSAIDs) and anti-TNF drugs. Objectives: The primary purpose of this study is to carefully detect the clinical manifestations of patients, demographic characteristics, and the effectiveness of common medications in this disease. Patients and Methods: The present study is a retrospective descriptive study. The statistical population is 101 patients with SpA who have demographic information and items related to clinical conditions, radiographic findings and response to treatment. Results: One hundred one patients with SpA [46 (45.5%) female] with the age of 36.83± 10.45 years were studied. Around 66 patients (64.7%) had ankylosing spondylitis (AS), with the highest prevalence of AS. The most common clinical symptoms in patients were axial and peripheral/ extra-articular symptoms. The response to patients’ treatment were 61 patients (60.4%) had responded to the first stage of treatment, since only one patient needed to change the treatment steps in five times. Conclusion: We found, most patients with SpA were young patients. The most common radiological finding was Sacroiliitis. The most common clinical finding was extra-articular manifestations. Peripheral manifestations of the disease in women and axial images in men were common. The highest response to treatment was observed with the combination of indomethacin, sulfasalazine (SSZ) and indomethacin (alone).https://jprevepi.com/PDF/jpe-7-e23162.pdfspondyloarthropathysacroiliitistreatmentindomethacin |
| spellingShingle | Seyed Mohammad Hashem Montazeri Seyed Mojtaba Alavi Fatemeh Radmard Maryam Masoumi Mostafa Vahedian Spondyloarthritis; clinical manifestations and evaluation of response to treatment in Iran Journal of Preventive Epidemiology spondyloarthropathy sacroiliitis treatment indomethacin |
| title | Spondyloarthritis; clinical manifestations and evaluation of response to treatment in Iran |
| title_full | Spondyloarthritis; clinical manifestations and evaluation of response to treatment in Iran |
| title_fullStr | Spondyloarthritis; clinical manifestations and evaluation of response to treatment in Iran |
| title_full_unstemmed | Spondyloarthritis; clinical manifestations and evaluation of response to treatment in Iran |
| title_short | Spondyloarthritis; clinical manifestations and evaluation of response to treatment in Iran |
| title_sort | spondyloarthritis clinical manifestations and evaluation of response to treatment in iran |
| topic | spondyloarthropathy sacroiliitis treatment indomethacin |
| url | https://jprevepi.com/PDF/jpe-7-e23162.pdf |
| work_keys_str_mv | AT seyedmohammadhashemmontazeri spondyloarthritisclinicalmanifestationsandevaluationofresponsetotreatmentiniran AT seyedmojtabaalavi spondyloarthritisclinicalmanifestationsandevaluationofresponsetotreatmentiniran AT fatemehradmard spondyloarthritisclinicalmanifestationsandevaluationofresponsetotreatmentiniran AT maryammasoumi spondyloarthritisclinicalmanifestationsandevaluationofresponsetotreatmentiniran AT mostafavahedian spondyloarthritisclinicalmanifestationsandevaluationofresponsetotreatmentiniran |