The Serotonin Receptor 6 Antagonist Idalopirdine and Acetylcholinesterase Inhibitor Donepezil Have Synergistic Effects on Brain Activity—A Functional MRI Study in the Awake Rat

The Serotonin Receptor 6 Antagonist Idalopirdine and Acetylcholinesterase Inhibitor Donepezil Have Synergistic Effects on Brain Activity—A Functional MRI Study in the Awake Rat

The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD) and other CNS disorders. The high-affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetyl...

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Bibliographic Details
Main Authors: Craig F. Ferris, Praveen Kulkarni, Jason R. Yee, Mark Nedelman, Inge E. M. de Jong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
serotonin
acetylcholine
BOLD fMRI
cognition
Alzheimer's disease
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00279/full

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