Natural and Artificial Mechanisms of Mitochondrial Genome Elimination
The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dyn...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/2/76 |
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| author | Elvira G. Zakirova Vladimir V. Muzyka Ilya O. Mazunin Konstantin E. Orishchenko |
| author_facet | Elvira G. Zakirova Vladimir V. Muzyka Ilya O. Mazunin Konstantin E. Orishchenko |
| author_sort | Elvira G. Zakirova |
| collection | DOAJ |
| description | The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dynamics in oogenesis and adult somatic cells. The current review summarizes present knowledge on the natural mechanisms of mitochondrial genome elimination during mammalian development. We also discuss the variety of existing and developing methodologies for artificial manipulation of the mtDNA heteroplasmy level. Understanding of the basics of mtDNA dynamics will shed the light on the pathogenesis and potential therapies of human diseases associated with mitochondrial dysfunction. |
| first_indexed | 2024-03-09T04:11:48Z |
| format | Article |
| id | doaj.art-900b2cb606f14701bfa0edf2c404a0ea |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T04:11:48Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-900b2cb606f14701bfa0edf2c404a0ea2023-12-03T13:59:27ZengMDPI AGLife2075-17292021-01-011127610.3390/life11020076Natural and Artificial Mechanisms of Mitochondrial Genome EliminationElvira G. Zakirova0Vladimir V. Muzyka1Ilya O. Mazunin2Konstantin E. Orishchenko3Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaFederal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaSkolkovo Institute of Science and Technology, 143026 Skolkovo, RussiaFederal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaThe generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dynamics in oogenesis and adult somatic cells. The current review summarizes present knowledge on the natural mechanisms of mitochondrial genome elimination during mammalian development. We also discuss the variety of existing and developing methodologies for artificial manipulation of the mtDNA heteroplasmy level. Understanding of the basics of mtDNA dynamics will shed the light on the pathogenesis and potential therapies of human diseases associated with mitochondrial dysfunction.https://www.mdpi.com/2075-1729/11/2/76mitochondrial DNA segregationheteroplasmyselective eliminationmitophagymitochondrial engineered nucleases |
| spellingShingle | Elvira G. Zakirova Vladimir V. Muzyka Ilya O. Mazunin Konstantin E. Orishchenko Natural and Artificial Mechanisms of Mitochondrial Genome Elimination Life mitochondrial DNA segregation heteroplasmy selective elimination mitophagy mitochondrial engineered nucleases |
| title | Natural and Artificial Mechanisms of Mitochondrial Genome Elimination |
| title_full | Natural and Artificial Mechanisms of Mitochondrial Genome Elimination |
| title_fullStr | Natural and Artificial Mechanisms of Mitochondrial Genome Elimination |
| title_full_unstemmed | Natural and Artificial Mechanisms of Mitochondrial Genome Elimination |
| title_short | Natural and Artificial Mechanisms of Mitochondrial Genome Elimination |
| title_sort | natural and artificial mechanisms of mitochondrial genome elimination |
| topic | mitochondrial DNA segregation heteroplasmy selective elimination mitophagy mitochondrial engineered nucleases |
| url | https://www.mdpi.com/2075-1729/11/2/76 |
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