Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support
Introduction: Vitamin D (VitD) classically recognized for its role in the musculoskeletal system, has been implicated in myriad of conditions such as diabetes, immune dysfunction, cancers, heart disease, metabolic syndrome, etc. We studied the role of VitD in acute care setting and its correlation w...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=4;spage=511;epage=515;aulast=Joshi |
| _version_ | 1831682583304339456 |
|---|---|
| author | Ameya Joshi Rakesh Bhadade Premlata K Varthakavi Rosmarie DeSouza Nikhil M Bhagwat Manoj D Chadha |
| author_facet | Ameya Joshi Rakesh Bhadade Premlata K Varthakavi Rosmarie DeSouza Nikhil M Bhagwat Manoj D Chadha |
| author_sort | Ameya Joshi |
| collection | DOAJ |
| description | Introduction: Vitamin D (VitD) classically recognized for its role in the musculoskeletal system, has been implicated in myriad of conditions such as diabetes, immune dysfunction, cancers, heart disease, metabolic syndrome, etc. We studied the role of VitD in acute care setting and its correlation with mortality. Materials and Methods: A total of 85 consecutive consenting patients admitted in medical intensive care unit of tertiary care hospital who fulfilled the inclusion criteria were included. All patients were evaluated clinically, and blood samples were collected for hemogram, biochemical investigations including serum calcium, phosphorus, alkaline phosphatase, magnesium, along with 25(OH) VitD, 1,25(OH) VitD and intact parathormone levels. Simplified acute physiology score (SAPS II) was calculated for all patients. Results: VitD was deficient (<30 ng/ml) in 27 patients (32%). The overall mortality was more in VitD deficient group as compared to VitD sufficient group (74 vs. 41%; P < 0.05). The actual mortality in VitD deficient group was higher than the mortality predicted by SAPS II score (50 vs. 74%; P < 0.0507). VitD deficiency was also associated with more mortality among those requiring ventilator support (95% vs. 40%; P < 0.05) as well as with higher blood glucose (124.5 ± 29.7 vs. 94.8 ± 19.8: P < 0.01) levels. Conclusion: VitD deficiency was associated with increased mortality, poor ventilator outcomes, and increased blood glucose in critically ill patients. |
| first_indexed | 2024-12-20T06:21:27Z |
| format | Article |
| id | doaj.art-900d4f3ea8de4ccfa6296a68b5f84135 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-20T06:21:27Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-900d4f3ea8de4ccfa6296a68b5f841352022-12-21T19:50:24ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002014-01-0118451151510.4103/2230-8210.137504Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory supportAmeya JoshiRakesh BhadadePremlata K VarthakaviRosmarie DeSouzaNikhil M BhagwatManoj D ChadhaIntroduction: Vitamin D (VitD) classically recognized for its role in the musculoskeletal system, has been implicated in myriad of conditions such as diabetes, immune dysfunction, cancers, heart disease, metabolic syndrome, etc. We studied the role of VitD in acute care setting and its correlation with mortality. Materials and Methods: A total of 85 consecutive consenting patients admitted in medical intensive care unit of tertiary care hospital who fulfilled the inclusion criteria were included. All patients were evaluated clinically, and blood samples were collected for hemogram, biochemical investigations including serum calcium, phosphorus, alkaline phosphatase, magnesium, along with 25(OH) VitD, 1,25(OH) VitD and intact parathormone levels. Simplified acute physiology score (SAPS II) was calculated for all patients. Results: VitD was deficient (<30 ng/ml) in 27 patients (32%). The overall mortality was more in VitD deficient group as compared to VitD sufficient group (74 vs. 41%; P < 0.05). The actual mortality in VitD deficient group was higher than the mortality predicted by SAPS II score (50 vs. 74%; P < 0.0507). VitD deficiency was also associated with more mortality among those requiring ventilator support (95% vs. 40%; P < 0.05) as well as with higher blood glucose (124.5 ± 29.7 vs. 94.8 ± 19.8: P < 0.01) levels. Conclusion: VitD deficiency was associated with increased mortality, poor ventilator outcomes, and increased blood glucose in critically ill patients.http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=4;spage=511;epage=515;aulast=JoshiBlood glucosemortalityvitamin D |
| spellingShingle | Ameya Joshi Rakesh Bhadade Premlata K Varthakavi Rosmarie DeSouza Nikhil M Bhagwat Manoj D Chadha Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support Indian Journal of Endocrinology and Metabolism Blood glucose mortality vitamin D |
| title | Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support |
| title_full | Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support |
| title_fullStr | Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support |
| title_full_unstemmed | Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support |
| title_short | Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support |
| title_sort | vitamin d deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support |
| topic | Blood glucose mortality vitamin D |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=4;spage=511;epage=515;aulast=Joshi |
| work_keys_str_mv | AT ameyajoshi vitaminddeficiencyisassociatedwithincreasedmortalityincriticallyillpatientsespeciallyinthoserequiringventilatorysupport AT rakeshbhadade vitaminddeficiencyisassociatedwithincreasedmortalityincriticallyillpatientsespeciallyinthoserequiringventilatorysupport AT premlatakvarthakavi vitaminddeficiencyisassociatedwithincreasedmortalityincriticallyillpatientsespeciallyinthoserequiringventilatorysupport AT rosmariedesouza vitaminddeficiencyisassociatedwithincreasedmortalityincriticallyillpatientsespeciallyinthoserequiringventilatorysupport AT nikhilmbhagwat vitaminddeficiencyisassociatedwithincreasedmortalityincriticallyillpatientsespeciallyinthoserequiringventilatorysupport AT manojdchadha vitaminddeficiencyisassociatedwithincreasedmortalityincriticallyillpatientsespeciallyinthoserequiringventilatorysupport |