Development and application of global assays of hyper‐ and hypofibrinolysis

Development and application of global assays of hyper‐ and hypofibrinolysis

Abstract Numerous methods for evaluation of global fibrinolytic activity in whole blood or plasma have been proposed, with the majority based on tissue‐type plasminogen activator (t‐PA) addition to initiate fibrinolysis. We propose that such an approach is useful to reveal hypofibrinolysis, but t‐PA...

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Bibliographic Details
Main Authors: Anton Ilich, Denis F. Noubouossie, Michael Henderson, Patrick Ellsworth, Kathleen F. Molitor, Elena Campello, Shannon Meeks, Amy Dunn, Myung S. Park, Rafal Pawlinski, Paolo Simioni, Amy Shapiro, Nigel S. Key
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
euglobulin clot lysis time
fibrinolysis
hemophilia
plasminogen
plasminogen activator inhibitor 1
Online Access:https://doi.org/10.1002/rth2.12275

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