CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways
CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/13/3943 |
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| author | Seyed Mohammad Gheibihayat Ricardo Cabezas Nikita G. Nikiforov Tannaz Jamialahmadi Thomas P. Johnston Amirhossein Sahebkar |
| author_facet | Seyed Mohammad Gheibihayat Ricardo Cabezas Nikita G. Nikiforov Tannaz Jamialahmadi Thomas P. Johnston Amirhossein Sahebkar |
| author_sort | Seyed Mohammad Gheibihayat |
| collection | DOAJ |
| description | CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesion, proliferation, apoptosis, migration, homeostasis, and the immune system. In this aspect, previous research has shown that CD47 modulates phagocytosis via macrophages, the transmigration of neutrophils, and the activation of T-cells, dendritic cells, and B-cells. Moreover, several studies have reported the increased expression of the CD47 receptor in a variety of diseases, including acute lymphoblastic leukemia (ALL), chronic myeloid leukemia, non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), bladder cancer, acute myeloid leukemia (AML), Gaucher disease, Multiple Sclerosis and stroke among others. The ubiquitous expression of the CD47 cell receptor on most resident cells of the CNS has previously been established through different methodologies. However, there is little information concerning its precise functions in the development of different neurodegenerative pathologies in the CNS. Consequently, further research pertaining to the specific functions and roles of CD47 and SIRP is required prior to its exploitation as a druggable approach for the targeting of various neurodegenerative diseases that affect the human population. The present review attempts to summarize the role of both CD47 and SIRP and their therapeutic potential in neurodegenerative disorders. |
| first_indexed | 2024-03-10T09:59:49Z |
| format | Article |
| id | doaj.art-900f96a9059147bbb35b6f3ea73cbaea |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:59:49Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-900f96a9059147bbb35b6f3ea73cbaea2023-11-22T02:02:05ZengMDPI AGMolecules1420-30492021-06-012613394310.3390/molecules26133943CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory PathwaysSeyed Mohammad Gheibihayat0Ricardo Cabezas1Nikita G. Nikiforov2Tannaz Jamialahmadi3Thomas P. Johnston4Amirhossein Sahebkar5Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd 8916188635, IranDepartment of Physiology, School of Medicine, Universidad Antonio Nariño, Bogotá 111511, ColombiaLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, Tsyurupa Street, 117418 Moscow, RussiaDepartment of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan 19395/1495, IranDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64131, USABiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 13944-91388, IranCD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesion, proliferation, apoptosis, migration, homeostasis, and the immune system. In this aspect, previous research has shown that CD47 modulates phagocytosis via macrophages, the transmigration of neutrophils, and the activation of T-cells, dendritic cells, and B-cells. Moreover, several studies have reported the increased expression of the CD47 receptor in a variety of diseases, including acute lymphoblastic leukemia (ALL), chronic myeloid leukemia, non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), bladder cancer, acute myeloid leukemia (AML), Gaucher disease, Multiple Sclerosis and stroke among others. The ubiquitous expression of the CD47 cell receptor on most resident cells of the CNS has previously been established through different methodologies. However, there is little information concerning its precise functions in the development of different neurodegenerative pathologies in the CNS. Consequently, further research pertaining to the specific functions and roles of CD47 and SIRP is required prior to its exploitation as a druggable approach for the targeting of various neurodegenerative diseases that affect the human population. The present review attempts to summarize the role of both CD47 and SIRP and their therapeutic potential in neurodegenerative disorders.https://www.mdpi.com/1420-3049/26/13/3943CD47SIRPαneurodegenerationmultiple sclerosisstrokeAlzheimer |
| spellingShingle | Seyed Mohammad Gheibihayat Ricardo Cabezas Nikita G. Nikiforov Tannaz Jamialahmadi Thomas P. Johnston Amirhossein Sahebkar CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways Molecules CD47 SIRPα neurodegeneration multiple sclerosis stroke Alzheimer |
| title | CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways |
| title_full | CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways |
| title_fullStr | CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways |
| title_full_unstemmed | CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways |
| title_short | CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways |
| title_sort | cd47 in the brain and neurodegeneration an update on the role in neuroinflammatory pathways |
| topic | CD47 SIRPα neurodegeneration multiple sclerosis stroke Alzheimer |
| url | https://www.mdpi.com/1420-3049/26/13/3943 |
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