CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesi...

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Bibliographic Details
Main Authors: Seyed Mohammad Gheibihayat, Ricardo Cabezas, Nikita G. Nikiforov, Tannaz Jamialahmadi, Thomas P. Johnston, Amirhossein Sahebkar
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
CD47
SIRPα
neurodegeneration
multiple sclerosis
stroke
Alzheimer
Online Access:https://www.mdpi.com/1420-3049/26/13/3943

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