CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection

CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection

Summary: The underlying mechanisms by which prior immunity to dengue virus (DENV) affords cross-protection against the related flavivirus Zika virus (ZIKV) are poorly understood. Here, we examine the ability of DENV/ZIKV-cross-reactive CD4+ T cells to protect against versus exacerbate ZIKV infection...

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Bibliographic Details
Main Authors: Jinsheng Wen, Ying-Ting Wang, Kristen M. Valentine, Rúbens Prince dos Santos Alves, Zhigang Xu, Jose Angel Regla-Nava, Annie Elong Ngono, Matthew P. Young, Luís C.S. Ferreira, Sujan Shresta
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305155

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