Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis
The envelope of hepatitis B virus (HBV), which is required for the entry to hepatocytes, consists of a lipid bilayer derived from hepatocyte and HBV envelope proteins, large/middle/small hepatitis B surface antigen (L/M/SHBs). The mechanisms and host factors for the envelope formation in the hepatoc...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1124 |
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| author | Jun Inoue Kosuke Sato Masashi Ninomiya Atsushi Masamune |
| author_facet | Jun Inoue Kosuke Sato Masashi Ninomiya Atsushi Masamune |
| author_sort | Jun Inoue |
| collection | DOAJ |
| description | The envelope of hepatitis B virus (HBV), which is required for the entry to hepatocytes, consists of a lipid bilayer derived from hepatocyte and HBV envelope proteins, large/middle/small hepatitis B surface antigen (L/M/SHBs). The mechanisms and host factors for the envelope formation in the hepatocytes are being revealed. HBV-infected hepatocytes release a large amount of subviral particles (SVPs) containing L/M/SHBs that facilitate escape from the immune system. Recently, novel drugs inhibiting the functions of the viral envelope and those inhibiting the release of SVPs have been reported. LHBs that accumulate in ER is considered to promote carcinogenesis and, especially, deletion mutants in the preS1/S2 domain have been reported to be associated with the development of hepatocellular carcinoma (HCC). In this review, we summarize recent reports on the findings regarding the biological characteristics of HBV envelope proteins, their involvement in HCC development and new agents targeting the envelope. |
| first_indexed | 2024-03-10T10:29:25Z |
| format | Article |
| id | doaj.art-9013126578b640b4a1fe1eb9c0d4eaf7 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:29:25Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-9013126578b640b4a1fe1eb9c0d4eaf72023-11-21T23:44:55ZengMDPI AGViruses1999-49152021-06-01136112410.3390/v13061124Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in CarcinogenesisJun Inoue0Kosuke Sato1Masashi Ninomiya2Atsushi Masamune3Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JapanThe envelope of hepatitis B virus (HBV), which is required for the entry to hepatocytes, consists of a lipid bilayer derived from hepatocyte and HBV envelope proteins, large/middle/small hepatitis B surface antigen (L/M/SHBs). The mechanisms and host factors for the envelope formation in the hepatocytes are being revealed. HBV-infected hepatocytes release a large amount of subviral particles (SVPs) containing L/M/SHBs that facilitate escape from the immune system. Recently, novel drugs inhibiting the functions of the viral envelope and those inhibiting the release of SVPs have been reported. LHBs that accumulate in ER is considered to promote carcinogenesis and, especially, deletion mutants in the preS1/S2 domain have been reported to be associated with the development of hepatocellular carcinoma (HCC). In this review, we summarize recent reports on the findings regarding the biological characteristics of HBV envelope proteins, their involvement in HCC development and new agents targeting the envelope.https://www.mdpi.com/1999-4915/13/6/1124HBVenvelopeDane particlesubviral particle |
| spellingShingle | Jun Inoue Kosuke Sato Masashi Ninomiya Atsushi Masamune Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis Viruses HBV envelope Dane particle subviral particle |
| title | Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis |
| title_full | Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis |
| title_fullStr | Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis |
| title_full_unstemmed | Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis |
| title_short | Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis |
| title_sort | envelope proteins of hepatitis b virus molecular biology and involvement in carcinogenesis |
| topic | HBV envelope Dane particle subviral particle |
| url | https://www.mdpi.com/1999-4915/13/6/1124 |
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