Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients
Introduction Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disorder. There is no consensus on the prognosis and management of LAMN. Materials and methods We reviewed 51 consecutive patients with LAMN from 2013 to 2018. We divided our patients into two groups. The first is patients with an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-08-01
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| Series: | Journal of Investigative Surgery |
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| Online Access: | http://dx.doi.org/10.1080/08941939.2019.1695986 |
| _version_ | 1797684682944413696 |
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| author | Jianchun Xiao Peiheng Li Wei Liu |
| author_facet | Jianchun Xiao Peiheng Li Wei Liu |
| author_sort | Jianchun Xiao |
| collection | DOAJ |
| description | Introduction Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disorder. There is no consensus on the prognosis and management of LAMN. Materials and methods We reviewed 51 consecutive patients with LAMN from 2013 to 2018. We divided our patients into two groups. The first is patients with an intact appendix. The second group comprises patients with the potential to develop a malignant condition. Comparisons of serum tumor markers between two groups were performed. Survival curves were estimated. Univariate and multivariate Cox proportional hazards were computed for 46 patients with median follow-up of 2.7 years. Results Comparison of patients in two groups revealed significant differences in the mean level and abnormal ratio of CA125 (p < 0.001, p < 0.001), CA19-9 (p = 0.04, p = 0.04), and CEA (p = 0.001, p = 0.02). Eight patients had relapsed by the last follow-up in the second group. Patients with normal CEA had significantly longer disease-free survival (DFS) time than those with abnormal CEA (p = 0.04). CA19-9 exhibited a significant association with DFS (HR = 5.72, p = 0.02) in the Univariate Cox proportional hazards. Discussion The prognosis of LAMN is related to serum tumor markers, the surgical procedure and the pathology. |
| first_indexed | 2024-03-12T00:33:14Z |
| format | Article |
| id | doaj.art-9013afc6fc894c2480642fd6f52373d0 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:33:14Z |
| publishDate | 2021-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-9013afc6fc894c2480642fd6f52373d02023-09-15T10:07:31ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532021-08-0134772172710.1080/08941939.2019.16959861695986Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN PatientsJianchun Xiao0Peiheng Li1Wei Liu2Department of General Surgery, Peking Union Medical College HospitalDepartment of General Surgery, Peking Union Medical College HospitalDepartment of General Surgery, Peking Union Medical College HospitalIntroduction Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disorder. There is no consensus on the prognosis and management of LAMN. Materials and methods We reviewed 51 consecutive patients with LAMN from 2013 to 2018. We divided our patients into two groups. The first is patients with an intact appendix. The second group comprises patients with the potential to develop a malignant condition. Comparisons of serum tumor markers between two groups were performed. Survival curves were estimated. Univariate and multivariate Cox proportional hazards were computed for 46 patients with median follow-up of 2.7 years. Results Comparison of patients in two groups revealed significant differences in the mean level and abnormal ratio of CA125 (p < 0.001, p < 0.001), CA19-9 (p = 0.04, p = 0.04), and CEA (p = 0.001, p = 0.02). Eight patients had relapsed by the last follow-up in the second group. Patients with normal CEA had significantly longer disease-free survival (DFS) time than those with abnormal CEA (p = 0.04). CA19-9 exhibited a significant association with DFS (HR = 5.72, p = 0.02) in the Univariate Cox proportional hazards. Discussion The prognosis of LAMN is related to serum tumor markers, the surgical procedure and the pathology.http://dx.doi.org/10.1080/08941939.2019.1695986low-grade appendiceal mucinous neoplasm (lamn)serum tumor markerclinical characteristicsprognosissurgeryimages |
| spellingShingle | Jianchun Xiao Peiheng Li Wei Liu Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients Journal of Investigative Surgery low-grade appendiceal mucinous neoplasm (lamn) serum tumor marker clinical characteristics prognosis surgery images |
| title | Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients |
| title_full | Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients |
| title_fullStr | Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients |
| title_full_unstemmed | Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients |
| title_short | Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients |
| title_sort | analysis of clinical characteristics of low grade appendiceal mucinous neoplasm lamn a retrospective cohort study of 51 lamn patients |
| topic | low-grade appendiceal mucinous neoplasm (lamn) serum tumor marker clinical characteristics prognosis surgery images |
| url | http://dx.doi.org/10.1080/08941939.2019.1695986 |
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