Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review
Nowadays androgenetic alopecia (AGA) has become a common concern of affected subjects of both sexes. Finasteride is approved by the Food and Drug Administration for the treatment of male AGA. There is no clear evidence to support the use of dutasteride in male AGA. In female AGA, the effectiveness...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2024-04-01
|
| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/dr/article/view/9909 |
| _version_ | 1797209907847495680 |
|---|---|
| author | Almuntaserbellah Almudaimeegh Hanadi AlMutairi Fatimah AlTassan Yomna AlQuraishi Khalid Nabil Nagshabandi |
| author_facet | Almuntaserbellah Almudaimeegh Hanadi AlMutairi Fatimah AlTassan Yomna AlQuraishi Khalid Nabil Nagshabandi |
| author_sort | Almuntaserbellah Almudaimeegh |
| collection | DOAJ |
| description |
Nowadays androgenetic alopecia (AGA) has become a common concern of affected subjects of both sexes. Finasteride is approved by the Food and Drug Administration for the treatment of male AGA. There is no clear evidence to support the use of dutasteride in male AGA. In female AGA, the effectiveness of dutasteride and finasteride is still under debate, and there is no clear evidence to use any of them in female AGA. A systematic review was conducted to compare between dutasteride and finasteride in treating both male and female AGA, and their efficacy, safety, side effects with effective dosage. The review was done using several databases including: PubMed, Ovid Medline, Google Scholar, and Cochrane using the following search terms/keywords: "Dutasteride" AND "Finasteride" AND "Male pattern hair loss" AND "Female pattern hair loss" AND "Efficacy", "Tolerability" AND "Side effects" AND "Comparison". To search for articles related to efficacy, tolerability, side effects, used doses of dutasteride and finasteride in the treatment of male and female AGA. The review encompassed a total of nine studies. Four randomized controlled trials, one single-arm trial, two prospective cohorts, and two retrospective cohort studies. Seven studies exclusively enrolled male participants, while only two included female participants. All groups receiving various doses of dutasteride and finasteride exhibited a significant increase in hair count compared to the placebo group. Notably, dutasteride (0.5 mg) and dutasteride (2.5 mg) were significantly more effective than finasteride (1 mg) in increasing hair counts. Furthermore, no significant difference in adverse events was observed between finasteride and dutasteride. Dutasteride is more potent than finasteride in treating AGA in both males and females. All the adverse events between finasteride and dutasteride were comparable.
|
| first_indexed | 2024-04-24T10:02:10Z |
| format | Article |
| id | doaj.art-90153fd8500f45f0989eed155523617f |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-04-24T10:02:10Z |
| publishDate | 2024-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-90153fd8500f45f0989eed155523617f2024-04-13T10:30:24ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062024-04-0110.4081/dr.2024.9909Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic reviewAlmuntaserbellah Almudaimeegh0Hanadi AlMutairi1Fatimah AlTassan2Yomna AlQuraishi3Khalid Nabil Nagshabandi4Department of Dermatology, King Saud University Medical City, Riyadh; College of Medicine, King Saud University, RiyadhDepartment of Dermatology, King Saud University Medical City, Riyadh; College of Medicine, King Saud University, RiyadhDepartment of Dermatology, King Fahad Medical City, RiyadhCollege of Medicine, AlQassim University, BurydahDepartment of Dermatology, King Saud University Medical City, Riyadh; College of Medicine, King Saud University, Riyadh Nowadays androgenetic alopecia (AGA) has become a common concern of affected subjects of both sexes. Finasteride is approved by the Food and Drug Administration for the treatment of male AGA. There is no clear evidence to support the use of dutasteride in male AGA. In female AGA, the effectiveness of dutasteride and finasteride is still under debate, and there is no clear evidence to use any of them in female AGA. A systematic review was conducted to compare between dutasteride and finasteride in treating both male and female AGA, and their efficacy, safety, side effects with effective dosage. The review was done using several databases including: PubMed, Ovid Medline, Google Scholar, and Cochrane using the following search terms/keywords: "Dutasteride" AND "Finasteride" AND "Male pattern hair loss" AND "Female pattern hair loss" AND "Efficacy", "Tolerability" AND "Side effects" AND "Comparison". To search for articles related to efficacy, tolerability, side effects, used doses of dutasteride and finasteride in the treatment of male and female AGA. The review encompassed a total of nine studies. Four randomized controlled trials, one single-arm trial, two prospective cohorts, and two retrospective cohort studies. Seven studies exclusively enrolled male participants, while only two included female participants. All groups receiving various doses of dutasteride and finasteride exhibited a significant increase in hair count compared to the placebo group. Notably, dutasteride (0.5 mg) and dutasteride (2.5 mg) were significantly more effective than finasteride (1 mg) in increasing hair counts. Furthermore, no significant difference in adverse events was observed between finasteride and dutasteride. Dutasteride is more potent than finasteride in treating AGA in both males and females. All the adverse events between finasteride and dutasteride were comparable. https://www.pagepress.org/journals/dr/article/view/9909Dutasteridefinasteridehair lossandrogenetic alopeciaside effects |
| spellingShingle | Almuntaserbellah Almudaimeegh Hanadi AlMutairi Fatimah AlTassan Yomna AlQuraishi Khalid Nabil Nagshabandi Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review Dermatology Reports Dutasteride finasteride hair loss androgenetic alopecia side effects |
| title | Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review |
| title_full | Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review |
| title_fullStr | Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review |
| title_full_unstemmed | Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review |
| title_short | Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review |
| title_sort | comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia a systematic review |
| topic | Dutasteride finasteride hair loss androgenetic alopecia side effects |
| url | https://www.pagepress.org/journals/dr/article/view/9909 |
| work_keys_str_mv | AT almuntaserbellahalmudaimeegh comparisonbetweendutasterideandfinasterideinhairregrowthandreversalofminiaturizationinmaleandfemaleandrogeneticalopeciaasystematicreview AT hanadialmutairi comparisonbetweendutasterideandfinasterideinhairregrowthandreversalofminiaturizationinmaleandfemaleandrogeneticalopeciaasystematicreview AT fatimahaltassan comparisonbetweendutasterideandfinasterideinhairregrowthandreversalofminiaturizationinmaleandfemaleandrogeneticalopeciaasystematicreview AT yomnaalquraishi comparisonbetweendutasterideandfinasterideinhairregrowthandreversalofminiaturizationinmaleandfemaleandrogeneticalopeciaasystematicreview AT khalidnabilnagshabandi comparisonbetweendutasterideandfinasterideinhairregrowthandreversalofminiaturizationinmaleandfemaleandrogeneticalopeciaasystematicreview |