Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle
Biofilm is a crucial virulence factor for microorganisms that causes chronic infection. After biofilm formation, the bacteria present improve drug tolerance and multifactorial defense mechanisms, which impose significant challenges for the use of antimicrobials. This indicates the urgent need for ne...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/15/10/1253 |
| _version_ | 1797470471334133760 |
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| author | Fanqiang Bu Mengnan Liu Zixu Xie Xinyu Chen Guofeng Li Xing Wang |
| author_facet | Fanqiang Bu Mengnan Liu Zixu Xie Xinyu Chen Guofeng Li Xing Wang |
| author_sort | Fanqiang Bu |
| collection | DOAJ |
| description | Biofilm is a crucial virulence factor for microorganisms that causes chronic infection. After biofilm formation, the bacteria present improve drug tolerance and multifactorial defense mechanisms, which impose significant challenges for the use of antimicrobials. This indicates the urgent need for new targeted technologies and emerging therapeutic strategies. In this review, we focus on the current biofilm-targeting strategies and those under development, including targeting persistent cells, quorum quenching, and phage therapy. We emphasize biofilm-targeting technologies that are supported by blocking the biofilm life cycle, providing a theoretical basis for design of targeting technology that disrupts the biofilm and promotes practical application of antibacterial materials. |
| first_indexed | 2024-03-09T19:36:42Z |
| format | Article |
| id | doaj.art-90167b60a32344c8aebcd64ae43a1fd4 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T19:36:42Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-90167b60a32344c8aebcd64ae43a1fd42023-11-24T01:51:56ZengMDPI AGPharmaceuticals1424-82472022-10-011510125310.3390/ph15101253Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life CycleFanqiang Bu0Mengnan Liu1Zixu Xie2Xinyu Chen3Guofeng Li4Xing Wang5State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, ChinaBiofilm is a crucial virulence factor for microorganisms that causes chronic infection. After biofilm formation, the bacteria present improve drug tolerance and multifactorial defense mechanisms, which impose significant challenges for the use of antimicrobials. This indicates the urgent need for new targeted technologies and emerging therapeutic strategies. In this review, we focus on the current biofilm-targeting strategies and those under development, including targeting persistent cells, quorum quenching, and phage therapy. We emphasize biofilm-targeting technologies that are supported by blocking the biofilm life cycle, providing a theoretical basis for design of targeting technology that disrupts the biofilm and promotes practical application of antibacterial materials.https://www.mdpi.com/1424-8247/15/10/1253biofilmmicroenvironmentbiofilm-targeting materialantibacterial |
| spellingShingle | Fanqiang Bu Mengnan Liu Zixu Xie Xinyu Chen Guofeng Li Xing Wang Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle Pharmaceuticals biofilm microenvironment biofilm-targeting material antibacterial |
| title | Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle |
| title_full | Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle |
| title_fullStr | Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle |
| title_full_unstemmed | Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle |
| title_short | Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle |
| title_sort | targeted anti biofilm therapy dissecting targets in the biofilm life cycle |
| topic | biofilm microenvironment biofilm-targeting material antibacterial |
| url | https://www.mdpi.com/1424-8247/15/10/1253 |
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