A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis
Subacute thyroiditis (SAT) is a thyroid disease associated with viral infections. Its relationship with major histocompatibility complex (MHC) antigens was shown before. SAT cases triggered by different types of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been reported...
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MDPI AG
2022-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/12/1986 |
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| author | Melisa Sahin Tekin Goknur Yorulmaz Emel Yantir Eren Gunduz Ertugrul Colak |
| author_facet | Melisa Sahin Tekin Goknur Yorulmaz Emel Yantir Eren Gunduz Ertugrul Colak |
| author_sort | Melisa Sahin Tekin |
| collection | DOAJ |
| description | Subacute thyroiditis (SAT) is a thyroid disease associated with viral infections. Its relationship with major histocompatibility complex (MHC) antigens was shown before. SAT cases triggered by different types of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been reported. In this study, human leukocyte antigen (HLA) genotypes of 27 SAT patients (13 vaccine-associated (V-SAT) and 14 non-SARS-CoV-2-infection non-vaccine-associated (non-V-SAT)) were compared with those of 362 healthy donors. HLA analyses were performed with low-resolution DNA-based sequence-specific oligonucleotide or sequence-specific primer methods. Statistical analyses were performed using IBM SPSS Statistics 25 and Stata/MP 14.1 with the hapipf function. Allele and haplotype frequencies were estimated by PyPop and gene[RATE] tool programs. The allele frequencies of HLA-A*11, HLA-B*35, and HLA-C*04 were higher in the patient groups. Both the allele frequency of HLA-A*11 and the haplotype frequency of A*11-B*35-C*04 were higher in the V-SAT group. The A*11-B*35-C*04 haplotype, including all three loci of MHC class I genes, is shown to be associated with the disease for the first time, especially in the V-SAT group. This finding will contribute to a better understanding of the etiopathogenesis of vaccine-associated SAT and the role of HLA genotypes in the functioning mechanisms of the SARS-CoV-2 vaccines. |
| first_indexed | 2024-03-09T15:45:54Z |
| format | Article |
| id | doaj.art-90170b9d16b4450f95f2cd04ae53cac6 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T15:45:54Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-90170b9d16b4450f95f2cd04ae53cac62023-11-24T18:30:40ZengMDPI AGVaccines2076-393X2022-11-011012198610.3390/vaccines10121986A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute ThyroiditisMelisa Sahin Tekin0Goknur Yorulmaz1Emel Yantir2Eren Gunduz3Ertugrul Colak4Department of Internal Medicine, Faculty of Medicine, Eskisehir Osmangazi University, 26040 Eskisehir, TurkeyDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, 26040 Eskisehir, TurkeyDepartment of Immunology, Faculty of Medicine, Eskisehir Osmangazi University, 26040 Eskisehir, TurkeyDepartment of Internal Medicine, Division of Hematology, Faculty of Medicine, Eskisehir Osmangazi University, 26040 Eskisehir, TurkeyDepartment of Biostatistics, Faculty of Medicine, Eskisehir Osmangazi University, 26040 Eskisehir, TurkeySubacute thyroiditis (SAT) is a thyroid disease associated with viral infections. Its relationship with major histocompatibility complex (MHC) antigens was shown before. SAT cases triggered by different types of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been reported. In this study, human leukocyte antigen (HLA) genotypes of 27 SAT patients (13 vaccine-associated (V-SAT) and 14 non-SARS-CoV-2-infection non-vaccine-associated (non-V-SAT)) were compared with those of 362 healthy donors. HLA analyses were performed with low-resolution DNA-based sequence-specific oligonucleotide or sequence-specific primer methods. Statistical analyses were performed using IBM SPSS Statistics 25 and Stata/MP 14.1 with the hapipf function. Allele and haplotype frequencies were estimated by PyPop and gene[RATE] tool programs. The allele frequencies of HLA-A*11, HLA-B*35, and HLA-C*04 were higher in the patient groups. Both the allele frequency of HLA-A*11 and the haplotype frequency of A*11-B*35-C*04 were higher in the V-SAT group. The A*11-B*35-C*04 haplotype, including all three loci of MHC class I genes, is shown to be associated with the disease for the first time, especially in the V-SAT group. This finding will contribute to a better understanding of the etiopathogenesis of vaccine-associated SAT and the role of HLA genotypes in the functioning mechanisms of the SARS-CoV-2 vaccines.https://www.mdpi.com/2076-393X/10/12/1986subacute thyroiditisSARS-CoV-2mRNA vaccinesHLA-A*11MHC class IHLA-A*11-B*35-C*04 haplotype |
| spellingShingle | Melisa Sahin Tekin Goknur Yorulmaz Emel Yantir Eren Gunduz Ertugrul Colak A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis Vaccines subacute thyroiditis SARS-CoV-2 mRNA vaccines HLA-A*11 MHC class I HLA-A*11-B*35-C*04 haplotype |
| title | A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis |
| title_full | A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis |
| title_fullStr | A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis |
| title_full_unstemmed | A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis |
| title_short | A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis |
| title_sort | novel finding of an hla allele s and a haplotype s relationship with sars cov 2 vaccine associated subacute thyroiditis |
| topic | subacute thyroiditis SARS-CoV-2 mRNA vaccines HLA-A*11 MHC class I HLA-A*11-B*35-C*04 haplotype |
| url | https://www.mdpi.com/2076-393X/10/12/1986 |
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