Influence of initial treatment modality on long-term control of chronic idiopathic urticaria.
<h4>Background</h4>Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term co...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935990/?tool=EBI |
| _version_ | 1818575271198982144 |
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| author | Sujeong Kim Seunghee Baek Bomi Shin Sun-young Yoon So Young Park Taehoon Lee Yoon Su Lee Yun-Jeong Bae Hyouk Soo Kwon You Sook Cho Hee-Bom Moon Tae-Bum Kim |
| author_facet | Sujeong Kim Seunghee Baek Bomi Shin Sun-young Yoon So Young Park Taehoon Lee Yoon Su Lee Yun-Jeong Bae Hyouk Soo Kwon You Sook Cho Hee-Bom Moon Tae-Bum Kim |
| author_sort | Sujeong Kim |
| collection | DOAJ |
| description | <h4>Background</h4>Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term control.<h4>Methods and results</h4>641 CIU patients were enrolled from the allergy clinic in a tertiary referral hospital. Disease duration, aggravating factors and treatment modality at each visit were evaluated. Times required to reach a controlled state were analyzed according to initial treatment modality, using Kaplan-Meier survival curves, the Cox proportional-hazards model, and propensity scores. Female to male ratio was 1.7: 1; mean age at onset was 40.5 years. The most common aggravating factors were food (33.5%), stress (31.5%) and fatigue (21.6%). Most patients (82.2%) used H1-antihistamines alone as initial treatment while 17% used a combination treatment with oral corticosteroids. There was no significant difference in the time taken to reach a controlled state between patients treated with single vs multiple H1-antihistamines or between those who received H1-antihistamine monotherapy vs. a combination therapy with oral corticosteroids.<h4>Conclusion</h4>The time required to control CIU is not reduced by use of multiple H1-antihistamines or oral corticosteroids in the initial treatment. |
| first_indexed | 2024-12-15T00:38:03Z |
| format | Article |
| id | doaj.art-901a25b168e847178eb6cb590ec07f83 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:38:03Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-901a25b168e847178eb6cb590ec07f832022-12-21T22:41:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6934510.1371/journal.pone.0069345Influence of initial treatment modality on long-term control of chronic idiopathic urticaria.Sujeong KimSeunghee BaekBomi ShinSun-young YoonSo Young ParkTaehoon LeeYoon Su LeeYun-Jeong BaeHyouk Soo KwonYou Sook ChoHee-Bom MoonTae-Bum Kim<h4>Background</h4>Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term control.<h4>Methods and results</h4>641 CIU patients were enrolled from the allergy clinic in a tertiary referral hospital. Disease duration, aggravating factors and treatment modality at each visit were evaluated. Times required to reach a controlled state were analyzed according to initial treatment modality, using Kaplan-Meier survival curves, the Cox proportional-hazards model, and propensity scores. Female to male ratio was 1.7: 1; mean age at onset was 40.5 years. The most common aggravating factors were food (33.5%), stress (31.5%) and fatigue (21.6%). Most patients (82.2%) used H1-antihistamines alone as initial treatment while 17% used a combination treatment with oral corticosteroids. There was no significant difference in the time taken to reach a controlled state between patients treated with single vs multiple H1-antihistamines or between those who received H1-antihistamine monotherapy vs. a combination therapy with oral corticosteroids.<h4>Conclusion</h4>The time required to control CIU is not reduced by use of multiple H1-antihistamines or oral corticosteroids in the initial treatment.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935990/?tool=EBI |
| spellingShingle | Sujeong Kim Seunghee Baek Bomi Shin Sun-young Yoon So Young Park Taehoon Lee Yoon Su Lee Yun-Jeong Bae Hyouk Soo Kwon You Sook Cho Hee-Bom Moon Tae-Bum Kim Influence of initial treatment modality on long-term control of chronic idiopathic urticaria. PLoS ONE |
| title | Influence of initial treatment modality on long-term control of chronic idiopathic urticaria. |
| title_full | Influence of initial treatment modality on long-term control of chronic idiopathic urticaria. |
| title_fullStr | Influence of initial treatment modality on long-term control of chronic idiopathic urticaria. |
| title_full_unstemmed | Influence of initial treatment modality on long-term control of chronic idiopathic urticaria. |
| title_short | Influence of initial treatment modality on long-term control of chronic idiopathic urticaria. |
| title_sort | influence of initial treatment modality on long term control of chronic idiopathic urticaria |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935990/?tool=EBI |
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