An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
Hydra regenerate various body parts on amputation by activation of the appropriate organiser, but how head formation is controlled is unclear. Here, the authors identify the transcription factor Sp5 as restricting head formation, by being activated by beta-catenin and then acting as a repressor of W...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-08242-2 |
| _version_ | 1818992002956525568 |
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| author | Matthias C. Vogg Leonardo Beccari Laura Iglesias Ollé Christine Rampon Sophie Vriz Chrystelle Perruchoud Yvan Wenger Brigitte Galliot |
| author_facet | Matthias C. Vogg Leonardo Beccari Laura Iglesias Ollé Christine Rampon Sophie Vriz Chrystelle Perruchoud Yvan Wenger Brigitte Galliot |
| author_sort | Matthias C. Vogg |
| collection | DOAJ |
| description | Hydra regenerate various body parts on amputation by activation of the appropriate organiser, but how head formation is controlled is unclear. Here, the authors identify the transcription factor Sp5 as restricting head formation, by being activated by beta-catenin and then acting as a repressor of Wnt3. |
| first_indexed | 2024-12-20T20:19:14Z |
| format | Article |
| id | doaj.art-901a72a74dfc4da789e63b0de3b155d0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:19:14Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-901a72a74dfc4da789e63b0de3b155d02022-12-21T19:27:37ZengNature PortfolioNature Communications2041-17232019-01-0110111510.1038/s41467-018-08242-2An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in HydraMatthias C. Vogg0Leonardo Beccari1Laura Iglesias Ollé2Christine Rampon3Sophie Vriz4Chrystelle Perruchoud5Yvan Wenger6Brigitte Galliot7Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of GenevaDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of GenevaDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of GenevaCentre Interdisciplinaire de Recherche en Biologie (CIRB), CNRS UMR 7241/INSERM U1050/Collège de FranceCentre Interdisciplinaire de Recherche en Biologie (CIRB), CNRS UMR 7241/INSERM U1050/Collège de FranceDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of GenevaDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of GenevaDepartment of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of GenevaHydra regenerate various body parts on amputation by activation of the appropriate organiser, but how head formation is controlled is unclear. Here, the authors identify the transcription factor Sp5 as restricting head formation, by being activated by beta-catenin and then acting as a repressor of Wnt3.https://doi.org/10.1038/s41467-018-08242-2 |
| spellingShingle | Matthias C. Vogg Leonardo Beccari Laura Iglesias Ollé Christine Rampon Sophie Vriz Chrystelle Perruchoud Yvan Wenger Brigitte Galliot An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra Nature Communications |
| title | An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra |
| title_full | An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra |
| title_fullStr | An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra |
| title_full_unstemmed | An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra |
| title_short | An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra |
| title_sort | evolutionarily conserved wnt3 β catenin sp5 feedback loop restricts head organizer activity in hydra |
| url | https://doi.org/10.1038/s41467-018-08242-2 |
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