A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic phenotype has not been firmly established. We performed global metabolomics, lip...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
American Society for Clinical investigation
2021-08-01
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| 叢編: | JCI Insight |
| 主題: | |
| 在線閱讀: | https://doi.org/10.1172/jci.insight.149217 |
| _version_ | 1828807828433797120 |
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| author | Fredrik Hoel August Hoel Ina K.N. Pettersen Ingrid G. Rekeland Kristin Risa Kine Alme Kari Sørland Alexander Fosså Katarina Lien Ingrid Herder Hanne L. Thürmer Merete E. Gotaas Christoph Schäfer Rolf K. Berge Kristian Sommerfelt Hans-Peter Marti Olav Dahl Olav Mella Øystein Fluge Karl J. Tronstad |
| author_facet | Fredrik Hoel August Hoel Ina K.N. Pettersen Ingrid G. Rekeland Kristin Risa Kine Alme Kari Sørland Alexander Fosså Katarina Lien Ingrid Herder Hanne L. Thürmer Merete E. Gotaas Christoph Schäfer Rolf K. Berge Kristian Sommerfelt Hans-Peter Marti Olav Dahl Olav Mella Øystein Fluge Karl J. Tronstad |
| author_sort | Fredrik Hoel |
| collection | DOAJ |
| description | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic phenotype has not been firmly established. We performed global metabolomics, lipidomics, and hormone measurements, and we used exploratory data analyses to compare serum from 83 patients with ME/CFS and 35 healthy controls. Some changes were common in the patient group, and these were compatible with effects of elevated energy strain and altered utilization of fatty acids and amino acids as catabolic fuels. In addition, a set of heterogeneous effects reflected specific changes in 3 subsets of patients, and 2 of these expressed characteristic contexts of deregulated energy metabolism. The biological relevance of these metabolic phenotypes (metabotypes) was supported by clinical data and independent blood analyses. In summary, we report a map of common and context-dependent metabolic changes in ME/CFS, and some of them presented possible associations with clinical patient profiles. We suggest that elevated energy strain may result from exertion-triggered tissue hypoxia and lead to systemic metabolic adaptation and compensation. Through various mechanisms, such metabolic dysfunction represents a likely mediator of key symptoms in ME/CFS and possibly a target for supportive intervention. |
| first_indexed | 2024-12-12T08:31:41Z |
| format | Article |
| id | doaj.art-901b1669aa974902b55a2279b6b28774 |
| institution | Directory Open Access Journal |
| issn | 2379-3708 |
| language | English |
| last_indexed | 2024-12-12T08:31:41Z |
| publishDate | 2021-08-01 |
| publisher | American Society for Clinical investigation |
| record_format | Article |
| series | JCI Insight |
| spelling | doaj.art-901b1669aa974902b55a2279b6b287742022-12-22T00:31:05ZengAmerican Society for Clinical investigationJCI Insight2379-37082021-08-01616A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndromeFredrik HoelAugust HoelIna K.N. PettersenIngrid G. RekelandKristin RisaKine AlmeKari SørlandAlexander FossåKatarina LienIngrid HerderHanne L. ThürmerMerete E. GotaasChristoph SchäferRolf K. BergeKristian SommerfeltHans-Peter MartiOlav DahlOlav MellaØystein FlugeKarl J. TronstadMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic phenotype has not been firmly established. We performed global metabolomics, lipidomics, and hormone measurements, and we used exploratory data analyses to compare serum from 83 patients with ME/CFS and 35 healthy controls. Some changes were common in the patient group, and these were compatible with effects of elevated energy strain and altered utilization of fatty acids and amino acids as catabolic fuels. In addition, a set of heterogeneous effects reflected specific changes in 3 subsets of patients, and 2 of these expressed characteristic contexts of deregulated energy metabolism. The biological relevance of these metabolic phenotypes (metabotypes) was supported by clinical data and independent blood analyses. In summary, we report a map of common and context-dependent metabolic changes in ME/CFS, and some of them presented possible associations with clinical patient profiles. We suggest that elevated energy strain may result from exertion-triggered tissue hypoxia and lead to systemic metabolic adaptation and compensation. Through various mechanisms, such metabolic dysfunction represents a likely mediator of key symptoms in ME/CFS and possibly a target for supportive intervention.https://doi.org/10.1172/jci.insight.149217ImmunologyMetabolism |
| spellingShingle | Fredrik Hoel August Hoel Ina K.N. Pettersen Ingrid G. Rekeland Kristin Risa Kine Alme Kari Sørland Alexander Fosså Katarina Lien Ingrid Herder Hanne L. Thürmer Merete E. Gotaas Christoph Schäfer Rolf K. Berge Kristian Sommerfelt Hans-Peter Marti Olav Dahl Olav Mella Øystein Fluge Karl J. Tronstad A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome JCI Insight Immunology Metabolism |
| title | A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_full | A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_fullStr | A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_full_unstemmed | A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_short | A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_sort | map of metabolic phenotypes in patients with myalgic encephalomyelitis chronic fatigue syndrome |
| topic | Immunology Metabolism |
| url | https://doi.org/10.1172/jci.insight.149217 |
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