Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet the degree of peptide specificity of Treg-cell function, and whether Treg ligands can be used to manipulate Treg cell biology are unknown. H...

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Hlavní autoři: Ricardo A Fernandes, Chaoran Li, Gang Wang, Xinbo Yang, Christina S Savvides, Caleb R Glassman, Shen Dong, Eric Luxenberg, Leah V Sibener, Michael E Birnbaum, Christophe Benoist, Diane Mathis, K Christopher Garcia
Médium: Článek
Jazyk:English
Vydáno: eLife Sciences Publications Ltd 2020-08-01
Edice:eLife
Témata:
inflammation
Treg cells
adipose tissue
surrogate antigens
On-line přístup:https://elifesciences.org/articles/58463

Internet

https://elifesciences.org/articles/58463

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