Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle
Background Circular RNAs (circRNAs) are identified as a novel family of endogenous RNA molecules through ‘back-splicing’ and covalently linked at the 5′ and 3′ ends. Emerging researches have demonstrated circRNAs are stable and abundant in exosomes called exosomal circRNAs (exo-circRNA).Materials an...
| المؤلفون الرئيسيون: | , , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Taylor & Francis Group
2024-12-01
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| سلاسل: | Annals of Medicine |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2420861 |
| _version_ | 1827011008834568192 |
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| author | Yuanyan Lou Jianing Yan Qingqing Liu Min Miao Yongfu Shao |
| author_facet | Yuanyan Lou Jianing Yan Qingqing Liu Min Miao Yongfu Shao |
| author_sort | Yuanyan Lou |
| collection | DOAJ |
| description | Background Circular RNAs (circRNAs) are identified as a novel family of endogenous RNA molecules through ‘back-splicing’ and covalently linked at the 5′ and 3′ ends. Emerging researches have demonstrated circRNAs are stable and abundant in exosomes called exosomal circRNAs (exo-circRNA).Materials and methods We searched recent studies and references to summary the research progress of exosomal circRNA.Results Recent studies have revealed that exosome-derived circRNAs including exo-CDR1as, exo-circRanGAP1, exo-circIAR play vital roles in cell proliferation and apoptosis, epithelial mesenchymal transition, invasion and metastasis, angiogenesis, immune evasion, cellular crosstalk, cancer cachexia through a variety of biological mechanisms, such as serving as microRNA sponges, interacting with RNA binding proteins, regulating gene transcription, N6-Methyladenosine modification and so on. Due to their characteristics of origin, structure, properties and biological functions, exo-circRNAs are expected to apply in precious diagnosis and prognostic indicators, improving drug and radiation resistance and sensitivity, becoming biological therapeutic targets.Conclusion We summarize the update of digestive malignancies associated exo-circRNAs in biogenesis, biological functions, molecular mechanisms, clinical implications, potential applications and experimental technique in order to effectively promote transformation and application in the future. |
| first_indexed | 2025-02-18T13:14:35Z |
| format | Article |
| id | doaj.art-901b3db239054cc49b76458418665a1f |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2025-02-18T13:14:35Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-901b3db239054cc49b76458418665a1f2024-11-01T09:38:57ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2024.2420861Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottleYuanyan Lou0Jianing Yan1Qingqing Liu2Min Miao3Yongfu Shao4Department of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaBackground Circular RNAs (circRNAs) are identified as a novel family of endogenous RNA molecules through ‘back-splicing’ and covalently linked at the 5′ and 3′ ends. Emerging researches have demonstrated circRNAs are stable and abundant in exosomes called exosomal circRNAs (exo-circRNA).Materials and methods We searched recent studies and references to summary the research progress of exosomal circRNA.Results Recent studies have revealed that exosome-derived circRNAs including exo-CDR1as, exo-circRanGAP1, exo-circIAR play vital roles in cell proliferation and apoptosis, epithelial mesenchymal transition, invasion and metastasis, angiogenesis, immune evasion, cellular crosstalk, cancer cachexia through a variety of biological mechanisms, such as serving as microRNA sponges, interacting with RNA binding proteins, regulating gene transcription, N6-Methyladenosine modification and so on. Due to their characteristics of origin, structure, properties and biological functions, exo-circRNAs are expected to apply in precious diagnosis and prognostic indicators, improving drug and radiation resistance and sensitivity, becoming biological therapeutic targets.Conclusion We summarize the update of digestive malignancies associated exo-circRNAs in biogenesis, biological functions, molecular mechanisms, clinical implications, potential applications and experimental technique in order to effectively promote transformation and application in the future.https://www.tandfonline.com/doi/10.1080/07853890.2024.2420861Exosomal circRNAexosomesdigestive malignanciesbiological functionmolecular mechanismclinical implication |
| spellingShingle | Yuanyan Lou Jianing Yan Qingqing Liu Min Miao Yongfu Shao Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle Annals of Medicine Exosomal circRNA exosomes digestive malignancies biological function molecular mechanism clinical implication |
| title | Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle |
| title_full | Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle |
| title_fullStr | Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle |
| title_full_unstemmed | Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle |
| title_short | Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle |
| title_sort | biological functions and molecular mechanisms of exosome derived circular rnas and their clinical implications in digestive malignancies the vintage in the bottle |
| topic | Exosomal circRNA exosomes digestive malignancies biological function molecular mechanism clinical implication |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2420861 |
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