Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil
This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth w...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-07-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867014000464 |
| _version_ | 1811300941117259776 |
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| author | Jaqueline Dario Capobiango Regina Mitsuka Breganó Italmar Teodorico Navarro Claudio Pereira Rezende Neto Antônio Marcelo Barbante Casella Fabiana Maria Ruiz Lopes Mori Sthefany Pagliari Inácio Teruo Inoue Edna Maria Vissoci Reiche |
| author_facet | Jaqueline Dario Capobiango Regina Mitsuka Breganó Italmar Teodorico Navarro Claudio Pereira Rezende Neto Antônio Marcelo Barbante Casella Fabiana Maria Ruiz Lopes Mori Sthefany Pagliari Inácio Teruo Inoue Edna Maria Vissoci Reiche |
| author_sort | Jaqueline Dario Capobiango |
| collection | DOAJ |
| description | This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was <2500 g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM antibodies were detected in 48.3% of the children. Imaging brain evaluation was normal in 44.8%; brain calcifications, hydrocephaly, or both conditions were observed in 27.6%, 10.3%, and 17.2%, respectively, of the patients. Patients with cerebrospinal fluid protein ≥ 200 mg/dL presented more brain calcifications (p = 0.0325). Other sequelae were visual impairment (55.2% of the cases), developmental delay (31.0%), motor deficit (13.8%), convulsion (27.5%), and attention deficit (10.3%). All patients were treated with sulfadiazine, pyrimethamine, and folinic acid, and 55.2% of them exhibited adverse effects. The results demonstrate the significance of the early diagnosis and treatment of toxoplasmosis during pregnancy to reduce congenital toxoplasmosis and its consequences. Keywords: Toxoplasma gondii, Congenital toxoplasmosis, Chorioretinitis, Diagnosis |
| first_indexed | 2024-04-13T06:59:58Z |
| format | Article |
| id | doaj.art-901d63e7fee449ec8b43ec2362fc6b45 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-04-13T06:59:58Z |
| publishDate | 2014-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-901d63e7fee449ec8b43ec2362fc6b452022-12-22T02:57:09ZengElsevierBrazilian Journal of Infectious Diseases1413-86702014-07-01184364371S1413-86702014000400364Congenital toxoplasmosis in a reference center of Paraná, Southern BrazilJaqueline Dario Capobiango0Regina Mitsuka Breganó1Italmar Teodorico Navarro2Claudio Pereira Rezende Neto3Antônio Marcelo Barbante Casella4Fabiana Maria Ruiz Lopes Mori5Sthefany Pagliari6Inácio Teruo Inoue7Edna Maria Vissoci Reiche8Department of Clinical Medicine, Health Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil; Corresponding author at: Department of Clinical Medicine, State University of Londrina, University Hospital, Street Robert Koch, 60, 86038-440, Londrina, PR, Brazil.Department of Pathological Sciences, Biological Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, BrazilDepartment of Veterinary, Agricultural Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, BrazilMedicine Course, Health Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, BrazilDepartment of Surgery, Health Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, BrazilCentro Universitário Filadélfia (UNIFIL), Londrina, PR, BrazilGraduate Program in Veterinary Medicine, Agricultural Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, BrazilDepartment of Gynecology and Obstetrics, Health Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, BrazilDepartment of Pathology, Clinical Analysis, and Toxicology, Health Sciences Center, Universidade Estadual de Londrina (UEL), Londrina, PR, BrazilThis study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was <2500 g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM antibodies were detected in 48.3% of the children. Imaging brain evaluation was normal in 44.8%; brain calcifications, hydrocephaly, or both conditions were observed in 27.6%, 10.3%, and 17.2%, respectively, of the patients. Patients with cerebrospinal fluid protein ≥ 200 mg/dL presented more brain calcifications (p = 0.0325). Other sequelae were visual impairment (55.2% of the cases), developmental delay (31.0%), motor deficit (13.8%), convulsion (27.5%), and attention deficit (10.3%). All patients were treated with sulfadiazine, pyrimethamine, and folinic acid, and 55.2% of them exhibited adverse effects. The results demonstrate the significance of the early diagnosis and treatment of toxoplasmosis during pregnancy to reduce congenital toxoplasmosis and its consequences. Keywords: Toxoplasma gondii, Congenital toxoplasmosis, Chorioretinitis, Diagnosishttp://www.sciencedirect.com/science/article/pii/S1413867014000464 |
| spellingShingle | Jaqueline Dario Capobiango Regina Mitsuka Breganó Italmar Teodorico Navarro Claudio Pereira Rezende Neto Antônio Marcelo Barbante Casella Fabiana Maria Ruiz Lopes Mori Sthefany Pagliari Inácio Teruo Inoue Edna Maria Vissoci Reiche Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil Brazilian Journal of Infectious Diseases |
| title | Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil |
| title_full | Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil |
| title_fullStr | Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil |
| title_full_unstemmed | Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil |
| title_short | Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil |
| title_sort | congenital toxoplasmosis in a reference center of parana southern brazil |
| url | http://www.sciencedirect.com/science/article/pii/S1413867014000464 |
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