Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions

Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions

The CARD–coiled coil (CC)/Bcl10/MALT1-like paracaspase (CBM) signaling complexes composed of a CARD–CC family member (CARD-9, -10, -11, or -14), Bcl10, and the type 1 paracaspase MALT1 (PCASP1) play a pivotal role in immunity, inflammation, and cancer. Targeting MALT1 proteolytic activity is of pote...

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Bibliographic Details
Main Authors: Jens Staal, Yasmine Driege, Mira Haegman, Alice Borghi, Paco Hulpiau, Laurens Lievens, Ismail Sahin Gul, Srividhya Sundararaman, Amanda Gonçalves, Ineke Dhondt, Jorge H. Pinzón, Bart P. Braeckman, Ulrich Technau, Yvan Saeys, Frans van Roy, Rudi Beyaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
signal transduction
molecular evolution
protein–protein interaction
structure–function analysis
NF-kappaB
coral bleaching
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01136/full

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