Bone Morphogenetic Protein 2 (BMP-2) Aggregates Can be Solubilized by Albumin—Investigation of BMP-2 Aggregation by Light Scattering and Electrophoresis

Bone Morphogenetic Protein 2 (BMP-2) Aggregates Can be Solubilized by Albumin—Investigation of BMP-2 Aggregation by Light Scattering and Electrophoresis

Bone morphogenetic protein 2 (BMP-2) has a high tendency to aggregate at physiological pH and physiological ionic strength, which can complicate the development of growth factor delivery systems. The aggregation behavior in differently concentrated BMP-2 solutions was investigated using dynamic and...

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Bibliographic Details
Main Authors: Julius Sundermann, Holger Zagst, Judith Kuntsche, Hermann Wätzig, Heike Bunjes
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
BMP-2
albumin
protein aggregation
protein-protein interactions
protein solubilization
Online Access:https://www.mdpi.com/1999-4923/12/12/1143

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https://www.mdpi.com/1999-4923/12/12/1143

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