SUMOylation and Major Depressive Disorder
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitoch...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/8023 |
| _version_ | 1797406113993326592 |
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| author | Seok-Won Jeoung Hyun-Sun Park Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu |
| author_facet | Seok-Won Jeoung Hyun-Sun Park Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu |
| author_sort | Seok-Won Jeoung |
| collection | DOAJ |
| description | Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD. |
| first_indexed | 2024-03-09T03:20:28Z |
| format | Article |
| id | doaj.art-901e8f3c3aab47049a258f129a89a0fa |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:20:28Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-901e8f3c3aab47049a258f129a89a0fa2023-12-03T15:10:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314802310.3390/ijms23148023SUMOylation and Major Depressive DisorderSeok-Won Jeoung0Hyun-Sun Park1Zae Young Ryoo2Dong-Hyung Cho3Hyun-Shik Lee4Hong-Yeoul Ryu5BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University, Daegu 41566, KoreaDepartment of Biochemistry, Inje University College of Medicine, Busan 50834, KoreaBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University, Daegu 41566, KoreaBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University, Daegu 41566, KoreaBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University, Daegu 41566, KoreaBK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University, Daegu 41566, KoreaSince the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD.https://www.mdpi.com/1422-0067/23/14/8023SUMOylationmajor depressive disorder (MDD)neuronsynapsemitochondria |
| spellingShingle | Seok-Won Jeoung Hyun-Sun Park Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu SUMOylation and Major Depressive Disorder International Journal of Molecular Sciences SUMOylation major depressive disorder (MDD) neuron synapse mitochondria |
| title | SUMOylation and Major Depressive Disorder |
| title_full | SUMOylation and Major Depressive Disorder |
| title_fullStr | SUMOylation and Major Depressive Disorder |
| title_full_unstemmed | SUMOylation and Major Depressive Disorder |
| title_short | SUMOylation and Major Depressive Disorder |
| title_sort | sumoylation and major depressive disorder |
| topic | SUMOylation major depressive disorder (MDD) neuron synapse mitochondria |
| url | https://www.mdpi.com/1422-0067/23/14/8023 |
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