Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

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Abstract A micro‐flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro‐flow transformation of N‐sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility...

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Bibliographic Details
Main Authors: Kazuki Hirano, Satoshi Gondo, Nagender Punna, Etsuko Tokunaga, Prof. Dr. Norio Shibata
Format: Article
Language:English
Published: Wiley-VCH 2019-04-01
Series:ChemistryOpen
Subjects:
flow chemistry
trifluoromethyl
fluoroform
micro-flow
gaseous
Online Access:https://doi.org/10.1002/open.201800286

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