Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

Abstract A micro‐flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro‐flow transformation of N‐sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility...

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Bibliografische gegevens
Hoofdauteurs: Kazuki Hirano, Satoshi Gondo, Nagender Punna, Etsuko Tokunaga, Prof. Dr. Norio Shibata
Formaat: Artikel
Taal:English
Gepubliceerd in: Wiley-VCH 2019-04-01
Reeks:ChemistryOpen
Onderwerpen:
Online toegang:https://doi.org/10.1002/open.201800286