THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS
Aim: The aim of this study is to investigate whether anisotropic diffusion is superior to conventional magnetic resonance imaging for understanding the pathophysiology of multiple sclerosis (MS) disease by Fractional anisotropy (FA) measurements. Material and Methods: In our study, FA measurements w...
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| Format: | Article |
| Language: | English |
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Rabia Yılmaz
2023-03-01
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| Series: | Journal of Contemporary Medicine |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2809330 |
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| author | A. Muhtesem Agıldere Ülkü Sibel Benli Eda Derle Gülay Maçin Fuldem Yıldırım Dönmez |
| author_facet | A. Muhtesem Agıldere Ülkü Sibel Benli Eda Derle Gülay Maçin Fuldem Yıldırım Dönmez |
| author_sort | A. Muhtesem Agıldere |
| collection | DOAJ |
| description | Aim: The aim of this study is to investigate whether anisotropic diffusion is superior to conventional magnetic resonance imaging for understanding the pathophysiology of multiple sclerosis (MS) disease by Fractional anisotropy (FA) measurements.
Material and Methods: In our study, FA measurements were made from the plaque, the periplaque area, the normal appeared white matter contralateral to the plaque and normal appearing white matter areas in MS patients and from the normal white matter in the control group. 3D trography maps were made in all MS patients and it was evaluated whether white pathways were affected by MS disease.
Results: When the degree of anisotropy was compared to the control group, the degree of plaques was found lowest. Increase was observed in periplaque, the normal appeared white matter contralateral to the plaque and normal appearing white matter, respectively. The active plaque FA value was found to be lower than the chronic plaque FA value, and the chronic plaque FA was found to be lower than the normal white matter FA value. It has been shown that plaques traced along axonal pathways in MS patients cause interruption in axonal pathways.
Conclusion: Progressive decrease in anisotropy from normal appearing white matter to periplaque white matter and plaque level indicates myelin damage. This suggests that the white matter that appears normal on T2 images on conventional MR is not actually normal. Based on these results, it was thought that diffusion tensor imaging would be useful in evaluating the burden of disease in MS patients. |
| first_indexed | 2024-04-09T21:50:52Z |
| format | Article |
| id | doaj.art-902165605bc74ad19eb64c90bf43e9d4 |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:50:52Z |
| publishDate | 2023-03-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-902165605bc74ad19eb64c90bf43e9d42023-03-24T19:43:20ZengRabia YılmazJournal of Contemporary Medicine2667-71802023-03-0113217017510.16899/jcm.12137431809THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTSA. Muhtesem Agıldere0Ülkü Sibel Benli1Eda Derle2Gülay Maçin3Fuldem Yıldırım Dönmez4Baskent University Faculty of Medicine Ankara Hospital, Department of RadiologyBaskent University Faculty of Medicine Ankara Hospital, Department of NeurologyBaskent University Faculty of Medicine Ankara Hospital, Department of NeurologyBeyhekim Training and Research Hospital, Radiology ClinicBaskent University Faculty of Medicine Ankara Hospital, Department of RadiologyAim: The aim of this study is to investigate whether anisotropic diffusion is superior to conventional magnetic resonance imaging for understanding the pathophysiology of multiple sclerosis (MS) disease by Fractional anisotropy (FA) measurements. Material and Methods: In our study, FA measurements were made from the plaque, the periplaque area, the normal appeared white matter contralateral to the plaque and normal appearing white matter areas in MS patients and from the normal white matter in the control group. 3D trography maps were made in all MS patients and it was evaluated whether white pathways were affected by MS disease. Results: When the degree of anisotropy was compared to the control group, the degree of plaques was found lowest. Increase was observed in periplaque, the normal appeared white matter contralateral to the plaque and normal appearing white matter, respectively. The active plaque FA value was found to be lower than the chronic plaque FA value, and the chronic plaque FA was found to be lower than the normal white matter FA value. It has been shown that plaques traced along axonal pathways in MS patients cause interruption in axonal pathways. Conclusion: Progressive decrease in anisotropy from normal appearing white matter to periplaque white matter and plaque level indicates myelin damage. This suggests that the white matter that appears normal on T2 images on conventional MR is not actually normal. Based on these results, it was thought that diffusion tensor imaging would be useful in evaluating the burden of disease in MS patients.https://dergipark.org.tr/tr/download/article-file/2809330multiple sclerosisdiffusion tensor imagingfractional anisotropymagnetic resonance imagingmultiple sclerosisdiffusion tensor imagingfractional anisotropymagnetic resonance imaging |
| spellingShingle | A. Muhtesem Agıldere Ülkü Sibel Benli Eda Derle Gülay Maçin Fuldem Yıldırım Dönmez THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS Journal of Contemporary Medicine multiple sclerosis diffusion tensor imaging fractional anisotropy magnetic resonance imaging multiple sclerosis diffusion tensor imaging fractional anisotropy magnetic resonance imaging |
| title | THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS |
| title_full | THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS |
| title_fullStr | THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS |
| title_full_unstemmed | THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS |
| title_short | THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS |
| title_sort | contribution of diffusion tensor imaging to conventional magnetic resonance imaging in the diagnosis of multiple sclerosis patients |
| topic | multiple sclerosis diffusion tensor imaging fractional anisotropy magnetic resonance imaging multiple sclerosis diffusion tensor imaging fractional anisotropy magnetic resonance imaging |
| url | https://dergipark.org.tr/tr/download/article-file/2809330 |
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