Local hemostatic biomaterial based on native collagen
The article presents the results of obtaining a neutral biomaterial in the form of a sponge based on the aqueous mass of collagen isolated from the hide of cattle while maintaining the original fibrous structure. It has been established that at a concentration of water mass of collagen of 5-6%, a hi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2023-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2023/57/e3sconf_ebwff2023_09004.pdf |
| _version_ | 1797673667121905664 |
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| author | Radjabov O.I. Otajonov A.Y. Baratov K.R. Azimova L.B. |
| author_facet | Radjabov O.I. Otajonov A.Y. Baratov K.R. Azimova L.B. |
| author_sort | Radjabov O.I. |
| collection | DOAJ |
| description | The article presents the results of obtaining a neutral biomaterial in the form of a sponge based on the aqueous mass of collagen isolated from the hide of cattle while maintaining the original fibrous structure. It has been established that at a concentration of water mass of collagen of 5-6%, a high porosity of the biomaterial is observed. With an increase in the porosity of the biomaterial, its sorption capacity increases. It is shown that the biomaterial “Hemogubka” with a porosity of 87% has a pronounced hemostatic effect in rabbits with increased bleeding, and also reduces the time of parenchymal bleeding of the liver, kidneys, and spleen in rabbits by 48-73%, respectively, and is superior in efficiency to the action of a hemostatic sponge and hemostatic gauze 1.2-1.5 times. |
| first_indexed | 2024-03-11T21:48:40Z |
| format | Article |
| id | doaj.art-902188531aaf46afa60e2031c125f4ee |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-03-11T21:48:40Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-902188531aaf46afa60e2031c125f4ee2023-09-26T10:10:51ZengEDP SciencesE3S Web of Conferences2267-12422023-01-014200900410.1051/e3sconf/202342009004e3sconf_ebwff2023_09004Local hemostatic biomaterial based on native collagenRadjabov O.I.0Otajonov A.Y.1Baratov K.R.2Azimova L.B.3Institute of Bioorganic ChemistryInstitute of Bioorganic ChemistryInstitute of Bioorganic ChemistryInstitute of Bioorganic ChemistryThe article presents the results of obtaining a neutral biomaterial in the form of a sponge based on the aqueous mass of collagen isolated from the hide of cattle while maintaining the original fibrous structure. It has been established that at a concentration of water mass of collagen of 5-6%, a high porosity of the biomaterial is observed. With an increase in the porosity of the biomaterial, its sorption capacity increases. It is shown that the biomaterial “Hemogubka” with a porosity of 87% has a pronounced hemostatic effect in rabbits with increased bleeding, and also reduces the time of parenchymal bleeding of the liver, kidneys, and spleen in rabbits by 48-73%, respectively, and is superior in efficiency to the action of a hemostatic sponge and hemostatic gauze 1.2-1.5 times.https://www.e3s-conferences.org/articles/e3sconf/pdf/2023/57/e3sconf_ebwff2023_09004.pdf |
| spellingShingle | Radjabov O.I. Otajonov A.Y. Baratov K.R. Azimova L.B. Local hemostatic biomaterial based on native collagen E3S Web of Conferences |
| title | Local hemostatic biomaterial based on native collagen |
| title_full | Local hemostatic biomaterial based on native collagen |
| title_fullStr | Local hemostatic biomaterial based on native collagen |
| title_full_unstemmed | Local hemostatic biomaterial based on native collagen |
| title_short | Local hemostatic biomaterial based on native collagen |
| title_sort | local hemostatic biomaterial based on native collagen |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2023/57/e3sconf_ebwff2023_09004.pdf |
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