Changes in brain perfusion with training-related visuomotor improvement in MS
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. A better understanding of the mechanisms supporting brain plasticity in MS would help to develop targeted interventions to promote recovery. A total of 29 MS patients and 19 healthy volunteers underwent clinical...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1270393/full |
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| author | Eleonora Patitucci Ilona Lipp Ilona Lipp Rachael Cecilia Stickland Richard G. Wise Richard G. Wise Richard G. Wise Valentina Tomassini Valentina Tomassini Valentina Tomassini Valentina Tomassini |
| author_facet | Eleonora Patitucci Ilona Lipp Ilona Lipp Rachael Cecilia Stickland Richard G. Wise Richard G. Wise Richard G. Wise Valentina Tomassini Valentina Tomassini Valentina Tomassini Valentina Tomassini |
| author_sort | Eleonora Patitucci |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. A better understanding of the mechanisms supporting brain plasticity in MS would help to develop targeted interventions to promote recovery. A total of 29 MS patients and 19 healthy volunteers underwent clinical assessment and multi-modal MRI acquisition [fMRI during serial reaction time task (SRT), DWI, T1w structural scans and ASL of resting perfusion] at baseline and after 4-weeks of SRT training. Reduction of functional hyperactivation was observed in MS patients following the training, shown by the stronger reduction of the BOLD response during task execution compared to healthy volunteers. The functional reorganization was accompanied by a positive correlation between improvements in task accuracy and the change in resting perfusion after 4 weeks’ training in right angular and supramarginal gyri in MS patients. No longitudinal changes in WM and GM measures and no correlation between task performance improvements and brain structure were observed in MS patients. Our results highlight a potential role for CBF as an early marker of plasticity, in terms of functional (cortical reorganization) and behavioral (performance improvement) changes in MS patients that may help to guide future interventions that exploit preserved plasticity mechanisms. |
| first_indexed | 2024-03-11T11:11:46Z |
| format | Article |
| id | doaj.art-90239e11dda749ac8e4f8230cffd3f41 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-11T11:11:46Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-90239e11dda749ac8e4f8230cffd3f412023-11-11T22:20:09ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-11-011610.3389/fnmol.2023.12703931270393Changes in brain perfusion with training-related visuomotor improvement in MSEleonora Patitucci0Ilona Lipp1Ilona Lipp2Rachael Cecilia Stickland3Richard G. Wise4Richard G. Wise5Richard G. Wise6Valentina Tomassini7Valentina Tomassini8Valentina Tomassini9Valentina Tomassini10Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff, United KingdomCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff, United KingdomMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff, United KingdomCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff, United KingdomInstitute for Advanced Biomedical Technologies, University of Chieti-Pescara “G. d’Annunzio,”Chieti, ItalyDepartment of Neurosciences, Imaging and Clinical Sciences, University of Chieti-Pescara “G. d’Annunzio,”Chieti, ItalyCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff, United KingdomInstitute for Advanced Biomedical Technologies, University of Chieti-Pescara “G. d’Annunzio,”Chieti, ItalyDepartment of Neurosciences, Imaging and Clinical Sciences, University of Chieti-Pescara “G. d’Annunzio,”Chieti, ItalyDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, United KingdomMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. A better understanding of the mechanisms supporting brain plasticity in MS would help to develop targeted interventions to promote recovery. A total of 29 MS patients and 19 healthy volunteers underwent clinical assessment and multi-modal MRI acquisition [fMRI during serial reaction time task (SRT), DWI, T1w structural scans and ASL of resting perfusion] at baseline and after 4-weeks of SRT training. Reduction of functional hyperactivation was observed in MS patients following the training, shown by the stronger reduction of the BOLD response during task execution compared to healthy volunteers. The functional reorganization was accompanied by a positive correlation between improvements in task accuracy and the change in resting perfusion after 4 weeks’ training in right angular and supramarginal gyri in MS patients. No longitudinal changes in WM and GM measures and no correlation between task performance improvements and brain structure were observed in MS patients. Our results highlight a potential role for CBF as an early marker of plasticity, in terms of functional (cortical reorganization) and behavioral (performance improvement) changes in MS patients that may help to guide future interventions that exploit preserved plasticity mechanisms.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1270393/fullmultiple sclerosisMRIperfusiontrainingplasticityrecovery |
| spellingShingle | Eleonora Patitucci Ilona Lipp Ilona Lipp Rachael Cecilia Stickland Richard G. Wise Richard G. Wise Richard G. Wise Valentina Tomassini Valentina Tomassini Valentina Tomassini Valentina Tomassini Changes in brain perfusion with training-related visuomotor improvement in MS Frontiers in Molecular Neuroscience multiple sclerosis MRI perfusion training plasticity recovery |
| title | Changes in brain perfusion with training-related visuomotor improvement in MS |
| title_full | Changes in brain perfusion with training-related visuomotor improvement in MS |
| title_fullStr | Changes in brain perfusion with training-related visuomotor improvement in MS |
| title_full_unstemmed | Changes in brain perfusion with training-related visuomotor improvement in MS |
| title_short | Changes in brain perfusion with training-related visuomotor improvement in MS |
| title_sort | changes in brain perfusion with training related visuomotor improvement in ms |
| topic | multiple sclerosis MRI perfusion training plasticity recovery |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1270393/full |
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