Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review
This systematic review aimed to investigate immune-inflammatory and hypothalamic-pituitary-adrenal (HPA) axis biomarkers in individuals with non-specific low back pain (NSLBP) compared to healthy control. The search was performed in five databases until 4 November 2021. Two reviewers independently c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.945513/full |
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| author | Juan P. Sanabria-Mazo Juan P. Sanabria-Mazo Juan P. Sanabria-Mazo Ariadna Colomer-Carbonell Ariadna Colomer-Carbonell Ariadna Colomer-Carbonell Meritxell Carmona-Cervelló Albert Feliu-Soler Xavier Borràs Mar Grasa Mar Grasa Montserrat Esteve Montserrat Esteve Michael Maes Sílvia Edo Antoni Sanz Juan V. Luciano Juan V. Luciano Juan V. Luciano |
| author_facet | Juan P. Sanabria-Mazo Juan P. Sanabria-Mazo Juan P. Sanabria-Mazo Ariadna Colomer-Carbonell Ariadna Colomer-Carbonell Ariadna Colomer-Carbonell Meritxell Carmona-Cervelló Albert Feliu-Soler Xavier Borràs Mar Grasa Mar Grasa Montserrat Esteve Montserrat Esteve Michael Maes Sílvia Edo Antoni Sanz Juan V. Luciano Juan V. Luciano Juan V. Luciano |
| author_sort | Juan P. Sanabria-Mazo |
| collection | DOAJ |
| description | This systematic review aimed to investigate immune-inflammatory and hypothalamic-pituitary-adrenal (HPA) axis biomarkers in individuals with non-specific low back pain (NSLBP) compared to healthy control. The search was performed in five databases until 4 November 2021. Two reviewers independently conducted screenings, data extraction, risk of bias, and methodological quality assessment of 14 unique studies. All studies reported the source of the fluid analyzed: nine studies used serum, two used plasma, one used serum and plasma, and two studies used salivary cortisol. We found preliminary and limited evidence (only one study for each biomarker) of increased levels in growth differentiation factor 15 (GDF-15), interleukin-23 (IL-23), transforming growth factor–beta (TGF-β), and soluble tumor necrosis factor receptor 1 (sTNF-R1) in NSLBP. Inconsistent and limited evidence was identified for interleukin-10 (IL-10). Although C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor–alpha (TNF-α) levels appear to increase in NSLBP, only one study per each biomarker reported statistically significant differences. Interleukin-1 beta (IL-1β), interleukin-17 (IL-17), interferon gamma (IFN-γ), and high-sensitivity CRP (hsCRP) showed no significant differences. Regarding cortisol, one study showed a significant increase and another a significant decrease. More robust evidence between GDF-15, IL-23, TGF-β, and sTNF-R1 with NSLBP is needed. Moreover, contrary to the findings reported in previous studies, when comparing results exclusively with healthy control, insufficient robust evidence for IL-6, TNF-α, and CRP was found in NSLBP. In addition, cortisol response (HPA-related biomarker) showed a dysregulated functioning in NSLBP, with incongruent evidence regarding its directionality. Therefore, our effort is to find adjusted evidence to conclude which immune-inflammatory and HPA axis biomarkers are altered in NSLBP and how much their levels are affected.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020176153, identifier CRD42020176153. |
| first_indexed | 2024-04-11T22:42:40Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T22:42:40Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-90247cc608fc4378a763f12b72c63a9e2022-12-22T03:58:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.945513945513Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic reviewJuan P. Sanabria-Mazo0Juan P. Sanabria-Mazo1Juan P. Sanabria-Mazo2Ariadna Colomer-Carbonell3Ariadna Colomer-Carbonell4Ariadna Colomer-Carbonell5Meritxell Carmona-Cervelló6Albert Feliu-Soler7Xavier Borràs8Mar Grasa9Mar Grasa10Montserrat Esteve11Montserrat Esteve12Michael Maes13Sílvia Edo14Antoni Sanz15Juan V. Luciano16Juan V. Luciano17Juan V. Luciano18Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, SpainTeaching, Research and Innovation Unit, Parc Sanitari Sant Joan de Déu, St. Boi de Llobregat, SpainFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainInstitut de Recerca Sant Joan de Déu, Esplugues de Llobregat, SpainTeaching, Research and Innovation Unit, Parc Sanitari Sant Joan de Déu, St. Boi de Llobregat, SpainFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainFaculty of Biology, University of Barcelona, Barcelona, SpainBiomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, SpainFaculty of Biology, University of Barcelona, Barcelona, SpainBiomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, SpainDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainInstitut de Recerca Sant Joan de Déu, Esplugues de Llobregat, SpainTeaching, Research and Innovation Unit, Parc Sanitari Sant Joan de Déu, St. Boi de Llobregat, SpainFaculty of Psychology, Autonomous University of Barcelona, Cerdanyola del Vallès, SpainThis systematic review aimed to investigate immune-inflammatory and hypothalamic-pituitary-adrenal (HPA) axis biomarkers in individuals with non-specific low back pain (NSLBP) compared to healthy control. The search was performed in five databases until 4 November 2021. Two reviewers independently conducted screenings, data extraction, risk of bias, and methodological quality assessment of 14 unique studies. All studies reported the source of the fluid analyzed: nine studies used serum, two used plasma, one used serum and plasma, and two studies used salivary cortisol. We found preliminary and limited evidence (only one study for each biomarker) of increased levels in growth differentiation factor 15 (GDF-15), interleukin-23 (IL-23), transforming growth factor–beta (TGF-β), and soluble tumor necrosis factor receptor 1 (sTNF-R1) in NSLBP. Inconsistent and limited evidence was identified for interleukin-10 (IL-10). Although C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor–alpha (TNF-α) levels appear to increase in NSLBP, only one study per each biomarker reported statistically significant differences. Interleukin-1 beta (IL-1β), interleukin-17 (IL-17), interferon gamma (IFN-γ), and high-sensitivity CRP (hsCRP) showed no significant differences. Regarding cortisol, one study showed a significant increase and another a significant decrease. More robust evidence between GDF-15, IL-23, TGF-β, and sTNF-R1 with NSLBP is needed. Moreover, contrary to the findings reported in previous studies, when comparing results exclusively with healthy control, insufficient robust evidence for IL-6, TNF-α, and CRP was found in NSLBP. In addition, cortisol response (HPA-related biomarker) showed a dysregulated functioning in NSLBP, with incongruent evidence regarding its directionality. Therefore, our effort is to find adjusted evidence to conclude which immune-inflammatory and HPA axis biomarkers are altered in NSLBP and how much their levels are affected.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020176153, identifier CRD42020176153.https://www.frontiersin.org/articles/10.3389/fimmu.2022.945513/fullnon-specific low back painimmune-inflammatory biomarkerscytokineshypothalamic-pituitary-adrenal axiscortisol |
| spellingShingle | Juan P. Sanabria-Mazo Juan P. Sanabria-Mazo Juan P. Sanabria-Mazo Ariadna Colomer-Carbonell Ariadna Colomer-Carbonell Ariadna Colomer-Carbonell Meritxell Carmona-Cervelló Albert Feliu-Soler Xavier Borràs Mar Grasa Mar Grasa Montserrat Esteve Montserrat Esteve Michael Maes Sílvia Edo Antoni Sanz Juan V. Luciano Juan V. Luciano Juan V. Luciano Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review Frontiers in Immunology non-specific low back pain immune-inflammatory biomarkers cytokines hypothalamic-pituitary-adrenal axis cortisol |
| title | Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review |
| title_full | Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review |
| title_fullStr | Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review |
| title_full_unstemmed | Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review |
| title_short | Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review |
| title_sort | immune inflammatory and hypothalamic pituitary adrenal axis biomarkers are altered in patients with non specific low back pain a systematic review |
| topic | non-specific low back pain immune-inflammatory biomarkers cytokines hypothalamic-pituitary-adrenal axis cortisol |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.945513/full |
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