Multi-modal Brain MRI in Subjects with PD and iRBD
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD. Here we aimed at piloting the characterization of brai...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2017.00709/full |
| _version_ | 1818138321654644736 |
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| author | Silvia Mangia Alena Svatkova Alena Svatkova Daniele Mascali Mikko J. Nissi Philip C. Burton Petr Bednarik Petr Bednarik Edward J. Auerbach Federico Giove Federico Giove Lynn E. Eberly Michael J. Howell Igor Nestrasil Paul J. Tuite Shalom Michaeli |
| author_facet | Silvia Mangia Alena Svatkova Alena Svatkova Daniele Mascali Mikko J. Nissi Philip C. Burton Petr Bednarik Petr Bednarik Edward J. Auerbach Federico Giove Federico Giove Lynn E. Eberly Michael J. Howell Igor Nestrasil Paul J. Tuite Shalom Michaeli |
| author_sort | Silvia Mangia |
| collection | DOAJ |
| description | Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD. Here we aimed at piloting the characterization of brain tissue properties in mid-brain subcortical regions of 10 healthy subjects, 8 iRBD, and 9 early-diagnosed PD. We used a battery of magnetic resonance imaging (MRI) contrasts at 3 T, including adiabatic and non-adiabatic rotating frame techniques developed by our group, along with diffusion tensor imaging (DTI) and resting-state fMRI. Adiabatic T1ρ and T2ρ, and non-adiabatic RAFF4 (Relaxation Along a Fictitious Field in the rotating frame of rank 4) were found to have lower coefficient of variations and higher sensitivity to detect group differences as compared to DTI parameters such as fractional anisotropy and mean diffusivity. Significantly longer T1ρ were observed in the amygdala of PD subjects vs. controls, along with a trend of lower functional connectivity as measured by regional homogeneity, thereby supporting the notion that amygdalar dysfunction occurs in PD. Significant abnormalities in reward networks occurred in iRBD subjects, who manifested lower network strength of the accumbens. In agreement with previous studies, significantly longer T1ρ occurred in the substantia nigra compacta of PD vs. controls, indicative of neuronal degeneration, while regional homogeneity was lower in the substantia nigra reticulata. Finally, other trend-level findings were observed, i.e., lower RAFF4 and T2ρ in the midbrain of iRBD subjects vs. controls, possibly indicating changes in non-motor features as opposed to motor function in the iRBD group. We conclude that rotating frame relaxation methods along with functional connectivity measures are valuable to characterize iRBD and PD subjects, and with proper validation in larger cohorts may provide pathological signatures of iRBD and PD. |
| first_indexed | 2024-12-11T10:10:21Z |
| format | Article |
| id | doaj.art-9024b27f4e004b11b2b2813eb44da472 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T10:10:21Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-9024b27f4e004b11b2b2813eb44da4722022-12-22T01:11:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-12-011110.3389/fnins.2017.00709274908Multi-modal Brain MRI in Subjects with PD and iRBDSilvia Mangia0Alena Svatkova1Alena Svatkova2Daniele Mascali3Mikko J. Nissi4Philip C. Burton5Petr Bednarik6Petr Bednarik7Edward J. Auerbach8Federico Giove9Federico Giove10Lynn E. Eberly11Michael J. Howell12Igor Nestrasil13Paul J. Tuite14Shalom Michaeli15Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United StatesDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, United StatesCentral European Institute of Technology (CEITEC), Masaryk University, Brno, CzechiaMARBILab, Centro Fermi - Museo Storico Della Fisica e Centro di Studi e Ricerche Enrico Fermi, Rome, ItalyDepartment of Applied Physics, University of Eastern Finland, Kuopio, FinlandDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United StatesDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United StatesCentral European Institute of Technology (CEITEC), Masaryk University, Brno, CzechiaDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United StatesMARBILab, Centro Fermi - Museo Storico Della Fisica e Centro di Studi e Ricerche Enrico Fermi, Rome, ItalyFondazione Santa Lucia IRCCS, Rome, ItalyDivision of Biostatistics, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United StatesIdiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD. Here we aimed at piloting the characterization of brain tissue properties in mid-brain subcortical regions of 10 healthy subjects, 8 iRBD, and 9 early-diagnosed PD. We used a battery of magnetic resonance imaging (MRI) contrasts at 3 T, including adiabatic and non-adiabatic rotating frame techniques developed by our group, along with diffusion tensor imaging (DTI) and resting-state fMRI. Adiabatic T1ρ and T2ρ, and non-adiabatic RAFF4 (Relaxation Along a Fictitious Field in the rotating frame of rank 4) were found to have lower coefficient of variations and higher sensitivity to detect group differences as compared to DTI parameters such as fractional anisotropy and mean diffusivity. Significantly longer T1ρ were observed in the amygdala of PD subjects vs. controls, along with a trend of lower functional connectivity as measured by regional homogeneity, thereby supporting the notion that amygdalar dysfunction occurs in PD. Significant abnormalities in reward networks occurred in iRBD subjects, who manifested lower network strength of the accumbens. In agreement with previous studies, significantly longer T1ρ occurred in the substantia nigra compacta of PD vs. controls, indicative of neuronal degeneration, while regional homogeneity was lower in the substantia nigra reticulata. Finally, other trend-level findings were observed, i.e., lower RAFF4 and T2ρ in the midbrain of iRBD subjects vs. controls, possibly indicating changes in non-motor features as opposed to motor function in the iRBD group. We conclude that rotating frame relaxation methods along with functional connectivity measures are valuable to characterize iRBD and PD subjects, and with proper validation in larger cohorts may provide pathological signatures of iRBD and PD.https://www.frontiersin.org/article/10.3389/fnins.2017.00709/fullrotating frame MRIParkinson's diseaseiRBDfunctional connectivityDTI |
| spellingShingle | Silvia Mangia Alena Svatkova Alena Svatkova Daniele Mascali Mikko J. Nissi Philip C. Burton Petr Bednarik Petr Bednarik Edward J. Auerbach Federico Giove Federico Giove Lynn E. Eberly Michael J. Howell Igor Nestrasil Paul J. Tuite Shalom Michaeli Multi-modal Brain MRI in Subjects with PD and iRBD Frontiers in Neuroscience rotating frame MRI Parkinson's disease iRBD functional connectivity DTI |
| title | Multi-modal Brain MRI in Subjects with PD and iRBD |
| title_full | Multi-modal Brain MRI in Subjects with PD and iRBD |
| title_fullStr | Multi-modal Brain MRI in Subjects with PD and iRBD |
| title_full_unstemmed | Multi-modal Brain MRI in Subjects with PD and iRBD |
| title_short | Multi-modal Brain MRI in Subjects with PD and iRBD |
| title_sort | multi modal brain mri in subjects with pd and irbd |
| topic | rotating frame MRI Parkinson's disease iRBD functional connectivity DTI |
| url | https://www.frontiersin.org/article/10.3389/fnins.2017.00709/full |
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