Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearance
<p>Abstract</p> <p>Background</p> <p>While the functional consequences of acute pulmonary infections are widely documented, few studies focused on chronic pneumonia. We evaluated the consequences of chronic <it>Pseudomonas </it>lung infection on alveolar fun...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-02-01
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| Series: | Respiratory Research |
| Online Access: | http://respiratory-research.com/content/6/1/17 |
| _version_ | 1811329399850532864 |
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| author | Prangere Thierry Kipnis Eric Husson Marie Ader Florence Faure Karine Boyer Sophie Leroy Xavier Guery Benoit P |
| author_facet | Prangere Thierry Kipnis Eric Husson Marie Ader Florence Faure Karine Boyer Sophie Leroy Xavier Guery Benoit P |
| author_sort | Prangere Thierry |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>While the functional consequences of acute pulmonary infections are widely documented, few studies focused on chronic pneumonia. We evaluated the consequences of chronic <it>Pseudomonas </it>lung infection on alveolar function.</p> <p>Methods</p> <p><it>P. aeruginosa</it>, included in agar beads, was instilled intratracheally in Sprague Dawley rats. Analysis was performed from day 2 to 21, a control group received only sterile agar beads. Alveolar-capillary barrier permeability, lung liquid clearance (LLC) and distal alveolar fluid clearance (DAFC) were measured using a vascular (<sup>131</sup>I-Albumin) and an alveolar tracer (<sup>125</sup>I-Albumin).</p> <p>Results</p> <p>The increase in permeability and LLC peaked on the second day, to return to baseline on the fifth. DAFC increased independently of TNF-α or endogenous catecholamine production. Despite the persistence of the pathogen within the alveoli, DAFC returned to baseline on the 5<sup>th </sup>day. Stimulation with terbutaline failed to increase DAFC. Eradication of the pathogen with ceftazidime did not restore DAFC response.</p> <p>Conclusions</p> <p>From these results, we observe an adequate initial alveolar response to increased permeability with an increase of DAFC. However, DAFC increase does not persist after the 5<sup>th </sup>day and remains unresponsive to stimulation. This impairment of DAFC may partly explain the higher susceptibility of chronically infected patients to subsequent lung injury.</p> |
| first_indexed | 2024-04-13T15:43:13Z |
| format | Article |
| id | doaj.art-9027b9e62d754abc9bced09857500d47 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-04-13T15:43:13Z |
| publishDate | 2005-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-9027b9e62d754abc9bced09857500d472022-12-22T02:41:05ZengBMCRespiratory Research1465-99212005-02-01611710.1186/1465-9921-6-17Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearancePrangere ThierryKipnis EricHusson MarieAder FlorenceFaure KarineBoyer SophieLeroy XavierGuery Benoit P<p>Abstract</p> <p>Background</p> <p>While the functional consequences of acute pulmonary infections are widely documented, few studies focused on chronic pneumonia. We evaluated the consequences of chronic <it>Pseudomonas </it>lung infection on alveolar function.</p> <p>Methods</p> <p><it>P. aeruginosa</it>, included in agar beads, was instilled intratracheally in Sprague Dawley rats. Analysis was performed from day 2 to 21, a control group received only sterile agar beads. Alveolar-capillary barrier permeability, lung liquid clearance (LLC) and distal alveolar fluid clearance (DAFC) were measured using a vascular (<sup>131</sup>I-Albumin) and an alveolar tracer (<sup>125</sup>I-Albumin).</p> <p>Results</p> <p>The increase in permeability and LLC peaked on the second day, to return to baseline on the fifth. DAFC increased independently of TNF-α or endogenous catecholamine production. Despite the persistence of the pathogen within the alveoli, DAFC returned to baseline on the 5<sup>th </sup>day. Stimulation with terbutaline failed to increase DAFC. Eradication of the pathogen with ceftazidime did not restore DAFC response.</p> <p>Conclusions</p> <p>From these results, we observe an adequate initial alveolar response to increased permeability with an increase of DAFC. However, DAFC increase does not persist after the 5<sup>th </sup>day and remains unresponsive to stimulation. This impairment of DAFC may partly explain the higher susceptibility of chronically infected patients to subsequent lung injury.</p>http://respiratory-research.com/content/6/1/17 |
| spellingShingle | Prangere Thierry Kipnis Eric Husson Marie Ader Florence Faure Karine Boyer Sophie Leroy Xavier Guery Benoit P Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearance Respiratory Research |
| title | Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearance |
| title_full | Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearance |
| title_fullStr | Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearance |
| title_full_unstemmed | Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearance |
| title_short | Chronic pneumonia with <it>Pseudomonas aeruginosa </it>and impaired alveolar fluid clearance |
| title_sort | chronic pneumonia with it pseudomonas aeruginosa it and impaired alveolar fluid clearance |
| url | http://respiratory-research.com/content/6/1/17 |
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