Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis.
Objective was to determine whether prophylactic low level laser therapy (LLLT) reduces the risk of severe mucositis as compared to placebo or no therapy.MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched until February 2014 for randomized controlled trials (RCTs) compa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4157876?pdf=render |
| _version_ | 1819156766723670016 |
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| author | Sapna Oberoi Gabriele Zamperlini-Netto Joseph Beyene Nathaniel S Treister Lillian Sung |
| author_facet | Sapna Oberoi Gabriele Zamperlini-Netto Joseph Beyene Nathaniel S Treister Lillian Sung |
| author_sort | Sapna Oberoi |
| collection | DOAJ |
| description | Objective was to determine whether prophylactic low level laser therapy (LLLT) reduces the risk of severe mucositis as compared to placebo or no therapy.MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched until February 2014 for randomized controlled trials (RCTs) comparing prophylactic LLLT with placebo or no therapy in patients with cancer or undergoing hematopoietic stem cell transplantation (HSCT). All analyses used random effects models.Eighteen RCTs (1144 patients) were included. Prophylactic LLLT reduced the overall risk of severe mucositis (risk ratio (RR) 0.37, 95% confidence interval (CI) 0.20 to 0.67; P = 0.001). LLLT also reduced the following outcomes when compared to placebo/no therapy: severe mucositis at the time of anticipated maximal mucositis (RR 0.34, 95% CI 0.20 to 0.59), overall mean grade of mucositis (standardized mean difference -1.49, 95% CI -2.02 to -0.95), duration of severe mucositis (weighted mean difference -5.32, 95% CI -9.45 to -1.19) and incidence of severe pain (RR 0.26, 95% CI 0.18 to 0.37).Prophylactic LLLT reduced severe mucositis and pain in patients with cancer and HSCT recipients. Future research should identify the optimal characteristics of LLLT and determine feasibility in the clinical setting. |
| first_indexed | 2024-12-22T15:58:05Z |
| format | Article |
| id | doaj.art-9028337fddd8426c9fe4c28dfdb74b74 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T15:58:05Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9028337fddd8426c9fe4c28dfdb74b742022-12-21T18:20:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10741810.1371/journal.pone.0107418Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis.Sapna OberoiGabriele Zamperlini-NettoJoseph BeyeneNathaniel S TreisterLillian SungObjective was to determine whether prophylactic low level laser therapy (LLLT) reduces the risk of severe mucositis as compared to placebo or no therapy.MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched until February 2014 for randomized controlled trials (RCTs) comparing prophylactic LLLT with placebo or no therapy in patients with cancer or undergoing hematopoietic stem cell transplantation (HSCT). All analyses used random effects models.Eighteen RCTs (1144 patients) were included. Prophylactic LLLT reduced the overall risk of severe mucositis (risk ratio (RR) 0.37, 95% confidence interval (CI) 0.20 to 0.67; P = 0.001). LLLT also reduced the following outcomes when compared to placebo/no therapy: severe mucositis at the time of anticipated maximal mucositis (RR 0.34, 95% CI 0.20 to 0.59), overall mean grade of mucositis (standardized mean difference -1.49, 95% CI -2.02 to -0.95), duration of severe mucositis (weighted mean difference -5.32, 95% CI -9.45 to -1.19) and incidence of severe pain (RR 0.26, 95% CI 0.18 to 0.37).Prophylactic LLLT reduced severe mucositis and pain in patients with cancer and HSCT recipients. Future research should identify the optimal characteristics of LLLT and determine feasibility in the clinical setting.http://europepmc.org/articles/PMC4157876?pdf=render |
| spellingShingle | Sapna Oberoi Gabriele Zamperlini-Netto Joseph Beyene Nathaniel S Treister Lillian Sung Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. PLoS ONE |
| title | Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. |
| title_full | Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. |
| title_fullStr | Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. |
| title_full_unstemmed | Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. |
| title_short | Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. |
| title_sort | effect of prophylactic low level laser therapy on oral mucositis a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC4157876?pdf=render |
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