FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo: Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis

FKS1 Is Required for Cryptococcus neoformans Fitness In Vivo: Application of Copper-Regulated Gene Expression to Mouse Models of Cryptococcosis

ABSTRACT There is an urgent need for new antifungals to treat cryptococcal meningoencephalitis, a leading cause of mortality in people living with HIV/AIDS. An important aspect of antifungal drug development is the validation of targets to determine whether they are required for the survival of the...

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Bibliographic Details
Main Authors: Sarah R. Beattie, Andrew J. Jezewski, Laura C. Ristow, Melanie Wellington, Damian J. Krysan
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mSphere
Subjects:
Cryptococcus neoformans
echinocandins
essential genes
glucan synthase
Online Access:https://journals.asm.org/doi/10.1128/msphere.00163-22

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