Origin and Migration of Olfactory Cajal-Retzius Cells
Early telencephalic development involves the migration of diverse cell types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnana.2017.00097/full |
| _version_ | 1830220528490643456 |
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| author | María Daniela Frade-Pérez Amaya Miquelajáuregui Alfredo Varela-Echavarría |
| author_facet | María Daniela Frade-Pérez Amaya Miquelajáuregui Alfredo Varela-Echavarría |
| author_sort | María Daniela Frade-Pérez |
| collection | DOAJ |
| description | Early telencephalic development involves the migration of diverse cell types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regions. One additional territory proposed to give rise to CR cells that migrate dorsally into the neocortex lies at the ventral pallium, although contradictory results question this notion. With the use of a cell-permeable fluorescent tracer in cultured embryos, we identified novel migratory paths of putative CR cells and other populations that originate from the rostrolateral telencephalon at its olfactory region. Moreover, extensive labeling on the lateral telencephalon along its rostro-caudal extent failed to reveal a dorsally-migrating CR cell population from the ventral pallium at the stages analyzed. Hence, this work reveals a novel olfactory CR cell migration and supports the idea that the ventral pallium, where diverse types of neurons converge, does not actually generate CR cells. |
| first_indexed | 2024-12-18T08:08:10Z |
| format | Article |
| id | doaj.art-902a105f8a33496baed1cc12ac4cd710 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-18T08:08:10Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-902a105f8a33496baed1cc12ac4cd7102022-12-21T21:14:57ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292017-11-011110.3389/fnana.2017.00097292570Origin and Migration of Olfactory Cajal-Retzius CellsMaría Daniela Frade-Pérez0Amaya Miquelajáuregui1Alfredo Varela-Echavarría2nstituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexiconstituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexiconstituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, MexicoEarly telencephalic development involves the migration of diverse cell types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regions. One additional territory proposed to give rise to CR cells that migrate dorsally into the neocortex lies at the ventral pallium, although contradictory results question this notion. With the use of a cell-permeable fluorescent tracer in cultured embryos, we identified novel migratory paths of putative CR cells and other populations that originate from the rostrolateral telencephalon at its olfactory region. Moreover, extensive labeling on the lateral telencephalon along its rostro-caudal extent failed to reveal a dorsally-migrating CR cell population from the ventral pallium at the stages analyzed. Hence, this work reveals a novel olfactory CR cell migration and supports the idea that the ventral pallium, where diverse types of neurons converge, does not actually generate CR cells.http://journal.frontiersin.org/article/10.3389/fnana.2017.00097/fulldevelopmenttelencephalonembryoLOTreelinmouse |
| spellingShingle | María Daniela Frade-Pérez Amaya Miquelajáuregui Alfredo Varela-Echavarría Origin and Migration of Olfactory Cajal-Retzius Cells Frontiers in Neuroanatomy development telencephalon embryo LOT reelin mouse |
| title | Origin and Migration of Olfactory Cajal-Retzius Cells |
| title_full | Origin and Migration of Olfactory Cajal-Retzius Cells |
| title_fullStr | Origin and Migration of Olfactory Cajal-Retzius Cells |
| title_full_unstemmed | Origin and Migration of Olfactory Cajal-Retzius Cells |
| title_short | Origin and Migration of Olfactory Cajal-Retzius Cells |
| title_sort | origin and migration of olfactory cajal retzius cells |
| topic | development telencephalon embryo LOT reelin mouse |
| url | http://journal.frontiersin.org/article/10.3389/fnana.2017.00097/full |
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