Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births
Abstract Uterine abnormalities infertility can be treated with implantable patches for tension‐free healing. However, the existing clinical patches are still limited in effective uterus recovery, resulting in low pregnancy and live birth rates. Herein, a novel engineered, and biocompatible Janus col...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-05-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202300051 |
| _version_ | 1797772535545200640 |
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| author | Xinyi Kang Wen Yang Xu Gao Ling Zhou Ziyang Yu Qun Dong Yanyan Chen Jianwu Dai Hong Zhang |
| author_facet | Xinyi Kang Wen Yang Xu Gao Ling Zhou Ziyang Yu Qun Dong Yanyan Chen Jianwu Dai Hong Zhang |
| author_sort | Xinyi Kang |
| collection | DOAJ |
| description | Abstract Uterine abnormalities infertility can be treated with implantable patches for tension‐free healing. However, the existing clinical patches are still limited in effective uterus recovery, resulting in low pregnancy and live birth rates. Herein, a novel engineered, and biocompatible Janus collagen patch (JCOP) is developed to achieve excellent uterine defect recovery and increase effective live births. The JCOP can highly match the structure, micromorphology, and mechanical properties of a natural uterus due to homologous‐like tissue homogeneity. JCOP's rough surface and loose‐extracellular‐matrix‐like porosity promote fibroblast adhesion and tissue regeneration, whereas its smooth surface reduces fibroblast adhesion and prevents visceral adhesions. Additionally, it exhibits exceptional resistance to swelling and deformation along with stable mechanical strength for long‐term preservation in the body and can withstand the highest uterine pressure in a humid interior environment attributed to its superior structural layout. Moreover, JCOP@bF, a functional JCOP linked to basic fibroblast growth factor (bFGF) via a specific collagen‐binding domain, significantly promotes repair of the injured uterus, restores the ability of the endometrium to accept embryos, and supports their development to a viable stage in a rat model of uterine damage. This study shows great promise for treating infertility caused by uterine damage. |
| first_indexed | 2024-03-12T21:52:22Z |
| format | Article |
| id | doaj.art-902d7b4340604d329312f1cb54f3fb52 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-12T21:52:22Z |
| publishDate | 2023-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-902d7b4340604d329312f1cb54f3fb522023-07-26T01:35:47ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-05-011013n/an/a10.1002/admi.202300051Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live BirthsXinyi Kang0Wen Yang1Xu Gao2Ling Zhou3Ziyang Yu4Qun Dong5Yanyan Chen6Jianwu Dai7Hong Zhang8Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University Suzhou 215004 ChinaKey Laboratory for Nano‐Bio Interface Research Division of Nano Biomedicine Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 ChinaKey Laboratory for Nano‐Bio Interface Research Division of Nano Biomedicine Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 ChinaDepartment of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University Suzhou 215004 ChinaDepartment of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University Suzhou 215004 ChinaDB Wuderegen Biomedical Technologies Co., Ltd Zhenjiang 212009 ChinaKey Laboratory for Nano‐Bio Interface Research Division of Nano Biomedicine Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 ChinaKey Laboratory for Nano‐Bio Interface Research Division of Nano Biomedicine Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 ChinaDepartment of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University Suzhou 215004 ChinaAbstract Uterine abnormalities infertility can be treated with implantable patches for tension‐free healing. However, the existing clinical patches are still limited in effective uterus recovery, resulting in low pregnancy and live birth rates. Herein, a novel engineered, and biocompatible Janus collagen patch (JCOP) is developed to achieve excellent uterine defect recovery and increase effective live births. The JCOP can highly match the structure, micromorphology, and mechanical properties of a natural uterus due to homologous‐like tissue homogeneity. JCOP's rough surface and loose‐extracellular‐matrix‐like porosity promote fibroblast adhesion and tissue regeneration, whereas its smooth surface reduces fibroblast adhesion and prevents visceral adhesions. Additionally, it exhibits exceptional resistance to swelling and deformation along with stable mechanical strength for long‐term preservation in the body and can withstand the highest uterine pressure in a humid interior environment attributed to its superior structural layout. Moreover, JCOP@bF, a functional JCOP linked to basic fibroblast growth factor (bFGF) via a specific collagen‐binding domain, significantly promotes repair of the injured uterus, restores the ability of the endometrium to accept embryos, and supports their development to a viable stage in a rat model of uterine damage. This study shows great promise for treating infertility caused by uterine damage.https://doi.org/10.1002/admi.202300051antiadhesionantideformationJanus collagen patchesprohealinguterine injuries |
| spellingShingle | Xinyi Kang Wen Yang Xu Gao Ling Zhou Ziyang Yu Qun Dong Yanyan Chen Jianwu Dai Hong Zhang Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births Advanced Materials Interfaces antiadhesion antideformation Janus collagen patches prohealing uterine injuries |
| title | Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births |
| title_full | Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births |
| title_fullStr | Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births |
| title_full_unstemmed | Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births |
| title_short | Biomimetic Janus Collagen Patch with Antideformation, Antiadhesion, and Prohealing Properties for Rehabilitation of Full‐Layer Uterine Injuries, Toward Efficient Live Births |
| title_sort | biomimetic janus collagen patch with antideformation antiadhesion and prohealing properties for rehabilitation of full layer uterine injuries toward efficient live births |
| topic | antiadhesion antideformation Janus collagen patches prohealing uterine injuries |
| url | https://doi.org/10.1002/admi.202300051 |
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