Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells

Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells

Abstract Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, the pharmacological effects of MT still need to be strengthened due to its relatively low efficacy and sh...

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Bibliographic Details
Main Authors: Yi Feng, Hai-yan Ying, Ying Qu, Xiao-bo Cai, Ming-yi Xu, Lun-gen Lu
Format: Article
Language:English
Published: Oxford University Press 2016-06-01
Series:Protein & Cell
Subjects:
matrine derivative
hepatic stellate cell
hepatic fibrosis
epidermal growth factor receptor
signal transduction pathway
Online Access:http://link.springer.com/article/10.1007/s13238-016-0285-2

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http://link.springer.com/article/10.1007/s13238-016-0285-2

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