Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia
An increased platelet distribution width (PDW) value has been found in various cardiovascular diseases. The objective of this study was to evaluate the association between the PDW and hypertension with hyperhomocysteinemia in an elderly cohort. We performed a cross-sectional analysis among 2,685 eld...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2019.1571600 |
| _version_ | 1797681306800226304 |
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| author | Gang Li Yanyan Zhang Zhongwei Zhu Juan Du |
| author_facet | Gang Li Yanyan Zhang Zhongwei Zhu Juan Du |
| author_sort | Gang Li |
| collection | DOAJ |
| description | An increased platelet distribution width (PDW) value has been found in various cardiovascular diseases. The objective of this study was to evaluate the association between the PDW and hypertension with hyperhomocysteinemia in an elderly cohort. We performed a cross-sectional analysis among 2,685 elderly individuals who underwent hematological testing and blood pressure assessment. Individuals were divided according to the PDW quartiles. An unconditional multiple logistic regression analysis was used to determine the association between PDW and hypertension with hyperhomocysteinemia, after adjustments for gender, age, drinking status, creatinine levels, glucose levels, uric acid levels, triglyceride levels, platelet counts and body mass index. Homocysteine was observed to steadily and remarkably increase in the PDW quartiles. The PDW values of the hypertension with hyperhomocysteinemia group were significantly greater than the PDW values in the hypertension without hyperhomocysteinemia group or the normotension group. The PDW levels were associated with hypertension and hyperhomocysteinemia independently of the previously mentioned risk factors, and the odds ratio of the hypertension with hyperhomocysteinemia group was steadily and remarkably increased, by as much as two-fold, in the fourth quartile vs. the first quartile. In this elderly population-based cohort, elevated PDW levels were independently associated with hypertension and hyperhomocysteinemia, which may indicate that hypertension and hyperhomocysteinemia can induce platelet activation. |
| first_indexed | 2024-03-11T23:43:05Z |
| format | Article |
| id | doaj.art-902f8771385c4cdaad8d8821a924e97e |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:05Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-902f8771385c4cdaad8d8821a924e97e2023-09-19T15:19:28ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062020-01-01421616610.1080/10641963.2019.15716001571600Evaluation of platelet distribution width in hypertension with hyperhomocysteinemiaGang Li0Yanyan Zhang1Zhongwei Zhu2Juan Du3Zhenhai Lianhua HospitalZhenhai Lianhua HospitalZhenhai Lianhua HospitalZhenhai Lianhua HospitalAn increased platelet distribution width (PDW) value has been found in various cardiovascular diseases. The objective of this study was to evaluate the association between the PDW and hypertension with hyperhomocysteinemia in an elderly cohort. We performed a cross-sectional analysis among 2,685 elderly individuals who underwent hematological testing and blood pressure assessment. Individuals were divided according to the PDW quartiles. An unconditional multiple logistic regression analysis was used to determine the association between PDW and hypertension with hyperhomocysteinemia, after adjustments for gender, age, drinking status, creatinine levels, glucose levels, uric acid levels, triglyceride levels, platelet counts and body mass index. Homocysteine was observed to steadily and remarkably increase in the PDW quartiles. The PDW values of the hypertension with hyperhomocysteinemia group were significantly greater than the PDW values in the hypertension without hyperhomocysteinemia group or the normotension group. The PDW levels were associated with hypertension and hyperhomocysteinemia independently of the previously mentioned risk factors, and the odds ratio of the hypertension with hyperhomocysteinemia group was steadily and remarkably increased, by as much as two-fold, in the fourth quartile vs. the first quartile. In this elderly population-based cohort, elevated PDW levels were independently associated with hypertension and hyperhomocysteinemia, which may indicate that hypertension and hyperhomocysteinemia can induce platelet activation.http://dx.doi.org/10.1080/10641963.2019.1571600platelet distribution widthhypertensionhyperhomocysteinemia |
| spellingShingle | Gang Li Yanyan Zhang Zhongwei Zhu Juan Du Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia Clinical and Experimental Hypertension platelet distribution width hypertension hyperhomocysteinemia |
| title | Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia |
| title_full | Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia |
| title_fullStr | Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia |
| title_full_unstemmed | Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia |
| title_short | Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia |
| title_sort | evaluation of platelet distribution width in hypertension with hyperhomocysteinemia |
| topic | platelet distribution width hypertension hyperhomocysteinemia |
| url | http://dx.doi.org/10.1080/10641963.2019.1571600 |
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